1.A.17.1.27
Anoctamin 7, ANO7, or TMEM16G, of 933 aas and 10 TMSs. It has calcium-dependent phospholipid
scramblase activity, scrambling phosphatidylserine, phosphatidylcholine
and galactosylceramide, but it does not exhibit
calcium-activated chloride channel (CaCC) activity. It may play a role in
cell-cell interactions (Das et al. 2008). ANO7 is associated with aggressive prostate cancer (Kaikkonen et al. 2018). Insights into the topology and function of Ano7 have been described (Guo et al. 2021). Activation of calcium-activated chloride channels suppresses inherited seizure susceptibility in genetically epilepsy-prone rats (Thomas et al. 2022).
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| Accession Number: | Q6IWH7 |
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| Protein Name: | Anoctamin-7 |
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| Length: | 933 |
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| Molecular Weight: | 105532.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
ion |
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1: MRMAATAWAG LQGPPLPTLC PAVRTGLYCR DQAHAERWAM TSETSSGSHC ARSRMLRRRA
61: QEEDSTVLID VSPPEAEKRG SYGSTAHASE PGGQQAAACR AGSPAKPRIA DFVLVWEEDL
121: KLDRQQDSAA RDRTDMHRTW RETFLDNLRA AGLCVDQQDV QDGNTTVHYA LLSASWAVLC
181: YYAEDLRLKL PLQELPNQAS NWSAGLLAWL GIPNVLLEVV PDVPPEYYSC RFRVNKLPRF
241: LGSDNQDTFF TSTKRHQILF EILAKTPYGH EKKNLLGIHQ LLAEGVLSAA FPLHDGPFKT
301: PPEGPQAPRL NQRQVLFQHW ARWGKWNKYQ PLDHVRRYFG EKVALYFAWL GFYTGWLLPA
361: AVVGTLVFLV GCFLVFSDIP TQELCGSKDS FEMCPLCLDC PFWLLSSACA LAQAGRLFDH
421: GGTVFFSLFM ALWAVLLLEY WKRKSATLAY RWDCSDYEDT EERPRPQFAA SAPMTAPNPI
481: TGEDEPYFPE RSRARRMLAG SVVIVVMVAV VVMCLVSIIL YRAIMAIVVS RSGNTLLAAW
541: ASRIASLTGS VVNLVFILIL SKIYVSLAHV LTRWEMHRTQ TKFEDAFTLK VFIFQFVNFY
601: SSPVYIAFFK GRFVGYPGNY HTLFGVRNEE CAAGGCLIEL AQELLVIMVG KQVINNMQEV
661: LIPKLKGWWQ KFRLRSKKRK AGASAGASQG PWEDDYELVP CEGLFDEYLE MVLQFGFVTI
721: FVAACPLAPL FALLNNWVEI RLDARKFVCE YRRPVAERAQ DIGIWFHILA GLTHLAVISN
781: AFLLAFSSDF LPRAYYRWTR AHDLRGFLNF TLARAPSSFA AAHNRTCRYR AFRDDDGHYS
841: QTYWNLLAIR LAFVIVFEHV VFSVGRLLDL LVPDIPESVE IKVKREYYLA KQALAENEVL
901: FGTNGTKDEQ PEGSELSSHW TPFTVPKASQ LQQ