1.A.17.1.28
Anoctamin1, Ano1, TMEM16A of 979 aas and 10 TMSs. It is probably an anion (Cl-) cannel. Fertilization activates TMEM16A channels in X. laevis eggs and induces the earliest known event triggered by fertilization: the fast block to polyspermy (Wozniak et al. 2018).
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| Accession Number: | B5SVV6 |
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| Protein Name: | Anoctamin |
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| Length: | 979 |
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| Molecular Weight: | 113226.00 |
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| Species: | Xenopus laevis (African clawed frog) [8355] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
inorganic anion, chloride |
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1: MIMAAKLDER VHEAPIPMNN INMDLLSQVG LTNLLNSLGA DRETGCKHGI FFKDGQRKVD
61: YILAFTYKKS GSRTPNKKNH HNNSVHNLHS PKDDHHLPGG GGDLEAMEAE PKMDYHEDDK
121: RFRREEYEGN LIETGLELER DEETKLHGVG FVKIHAPWNV LCREAEFMKL KMPTKKVYQI
181: NQTQGLMQKL SSFIHKISEP IQPKVAGLRP QTVKHLSYPF SREKQHLFDM SDKESFFDSK
241: TRSSIVYEIL KRTTCTKAKY SMGITSLLAN GVYSAAYPLH DGDYDSEAEA NDRKLLSDEW
301: ASYSAFYKYQ PIDLVRKYFG EKIGLYFAWL GVYTQMLIPA SVVGIIVFLY GCATVDENIP
361: SMEMCDTRYN ITMCPLCDRT CNYWKMSSAC GTARASHLFD NPATVFFSVF MALWAASFME
421: HWKRRQMRLN YRWDLTGFEE EEGMVKDHPR AEYEAKVLQK SLKKEYRSKE KQQHVPEDNP
481: NKWKQRVKTA MAGVKLTEKE KLTWRDRFPA YLTNVVGIIF MIGVTFAIVF GVIMYRISTA
541: AALAMSSNPN TRANVRVTVT ATAVIINLVV ILILDEVYGA IARWLTQIEV PKTDKTFEER
601: LIFKAFLLKF VNAYTPIFYV AFFKGRIVGR PGDYYYIFQS FRMEECAPGG CLMELCIQLS
661: IIMLGKQLIQ NNLFEIGIPK MKKLIRYLKS KRQSYKDHEE HLKKKQRYEE DYDLEPFAGL
721: TPEYMEMIIQ FGFVTLFVAS FPLAPLFALL NNIIEIRLDA KKFITELRRP VAVRAKDIGI
781: WYNIIRGVGK LAVIINAFVI SFTSDFIPRL VYLYMYSPDG TMHGFVNHTL SYFNVSDFKL
841: GTEPSQPVDL GYKVEMCRYK DYREAPWSLN KYDINKDYWA VLAARLAFVI VFQNLVMFMS
901: DFVDWIIPDI PKDISEQIHR EKVLMVEVFL KEEQGKLQML ETWKEHERKK GENCNSQSPG
961: LSRSQRGSSS SMYSHRVDV