1.A.17.4.1
TMC2, like TMC1, plays a role in hearing and gravity detection (Kawashima et al., 2011). Required for normal function of cochlear hair cells, possibly as a Ca2+ channel (Kim and Fettiplace 2013). TMC1 and TMC2 are both components of hair cell transduction channels and
contribute to permeation properties (Pan et al. 2013; Kawashima et al. 2014). Both TMC1 and 2 interact with Protocadherin 15 (Maeda et al. 2014). TMC1 and TMC2 are components of the stereocilia mechanoelectrical transduction channel complex (Kurima et al. 2015). While TMC2 is required for mechanotransduction in mature vestibular hair cells, its expression in the immature cochlea may be an evolutionary remnant (Corns et al. 2017). Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1 (Asai et al. 2018). Gentamicin and other antibiotics enters neonatal mouse hair cells predominantly through sensorymMechanoelectrical transduction channels, Tmc1 and Tmc2 (Makabe et al. 2020).
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| Accession Number: | Q8R4P4 |
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| Protein Name: | Transmembrane channel-like protein 2 |
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| Length: | 888 |
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| Molecular Weight: | 101134.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+) |
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| Entrez Gene ID: |
192140
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| Pfam: |
PF07810
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| KEGG: |
mmu:192140
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[1] “Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function.” Kurima K. et.al. 11850618
[2] “TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.” Keresztes G. et.al. 12812529
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1: MSPQLKSLDE EGDKSARRPT RKQTSRAACP QDGHRAQSSR KDPAKGSPRP GSSRKKQMEH
61: GSYHKGLQGQ KPRKVERSLQ GRKKDRRTSL KEQRASPKKE REALRKEAGK QLRKPRSTSL
121: GSSVSTGDSL SEEELAQILE QVEEKKKLIT TVRNKPWPMA KKLRELREAQ AFVEKYEGAL
181: GKGKGKHLYA YRMMMAKKWV KFKRDFDNFK TQCIPWEMKI KDIESHFGSS VASYFIFLRW
241: MYGVNLVLFG LIFGLVIIPE VLMGMPYGSI PRKTVPRAEE ERAMDFSVLW DFEGYIKYSA
301: LFYGYYNNQR TIGWLRYRLP MAYFMVGVSV FGYSLMIVIR SMASNTQGST SEGDSDSFTF
361: SFKMFTSWDY LIGNSETADN KYVSITTSFK ESIVDEQESN KEGNIHLTRF LRVLANFLIL
421: CCLCGSGYLI YFVVKRSQEF SKMQNVSWYE RNEVEIVMSL LGMFCPPLFE TIAALENYHP
481: RTGLKWQLGR IFALFLGNLY TFLLALMDDV HLKLSNEEKI KNITHWTLFN YYNSSGGNES
541: VPRPPPHPAD VPRGSCWETA VGIEFMRLTV SDMLVTYLTI LVGDFLRACF VRFMNHCWCW
601: DLEAGFPSYA EFDISGNVLG LIFNQGMIWM GSFYAPGLVG INVLRLLTSM YFQCWAVMSS
661: NVPHERVFKA SRSNNFYMGL LLLVLFLSLL PVAYTVMSLP PSFDCGPFSG KNRMYDVLHE
721: TIENDFPKFL GKIFAFLANP GLIIPAILLM FLAIYYLNSV SKSLSRANAQ LRKKIQALRE
781: VEKNHKSIKG KAIVTYSEDT IKNSSKNATQ IHLTKEEPTS HSSSQIQTLD KKAQGPHTSS
841: TEGGASPSTS WHHVGSQPPR GRRDSGQPQS QTYTGRSPSG KRTQRPHN