1.A.17.4.12
Transmembrane channel protein 3, Tmc3 of 1130 aas (Kurima et al. 2003; Beurg et al. 2014). LPS-inducible lncRNA TMC3-antisense-1 (AS1) negatively regulates the expression of IL-10 (Ye et al. 2020). In the brown planthopper, Nilaparvata lugens, TMCs is highly expressed in the female reproductive organ especially in the oviduct (Jia et al. 2020). RNAi-mediated silencing of Nltmc3 substantially decreased the egg-laying number and impaired ovary development.
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| Accession Number: | Q7TQ69 |
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| Protein Name: | Transmembrane channel-like protein 3 |
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| Length: | 1130 |
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| Molecular Weight: | 128691.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MKTSKASQRY RSIRRNASQC YLYQDSLLLG NSDDSFNADE TGDSSDPEQI FQNIQFQKDL
61: MANIRCRPWT MGQKLRALRR AKEIVLKFEG RLTRTRGYQA AGAELWRKFA RLACNFVVIF
121: IPWEMRIKKI ESHFGSGVAS YFIFLRWLFG INIVLTVMTG AFVVLPELIA GQPFGSTASK
181: TIPREQITSA QDLDTVWSLG GYLQYSVLFY GYYGRERRIG RAGYRLPLAY FLVGMAVFAY
241: SFIVLLKRMA KNSRTSLASA SNENYTFCWR VFCAWDYLIG NPEAAESKTA AILNSIREAI
301: LEEQEKKKNK NMAVTVCLRI IANILVLLSL AGSIYLIYFV VDRSQKLEQS KKELTLWEKN
361: EVSVVVSLVT MLAPSAFDLI AALEMYHPRT TLRFQLARVL VLYLGNLYSL IIALLDKVNS
421: MNIEEAATKN ITSHWADAPT FSATRTVPEE GQWPTPGSGA ELRRNTSTWV VEETSFLTSI
481: TPHTKANKTV PYMQGPQGQC WETYVGQEML KLSVIDMLFT VASILLIDFF RGLFVRYLSD
541: YWCWDLESKF PEYGEFKIAE NVLHLVYNQG MIWMGAFFSP CLPAFNVLKL IGLMYLRSWA
601: VLTCNVPHQQ VFRASRSNNF YLAMLLFMLF LCMLPTIFAI VHYKPSLNCG PFSGQEKIYD
661: IVSETIENDF PTWFHAVVGH ISSPVVILPA VLLLFMLIYY LQSIARSLKL SSQQLRMQIQ
721: NARSEDKKKV AQMVEALAIP SDARQAGSAT EAESSENSKP KTLQARIQTH EESSKRLLKD
781: SDLISQLSSV YMATSPNNGH MLNFDSLSSK SLRMEAITRS LPQSPGQGSR DPCSPLLDGS
841: RSRPEQDTNR HPHRPCSSTS NLHKNRSCSS VTQTQPLKDV RSEPLSRKDF QPISPPFCGS
901: GVSTLMTHDH SPRAPRYYVV NERDSHKKTH RAFWPERHFK IDALGDIVEL YPRNVQQYMS
961: WVPNQPCSPQ LSEEEEEMLR RDLVQWSIPA SSLTDLPRSS CFYTGDRSEN NTRDPKYQRR
1021: VYYRSGDNSF EDQLERPTFV HRKPRSRNGQ YPQHALKARV KAKFEPSFTE SDSVSAASSS
1081: DHQNSNNDQY LHVMSSQGRF PRSASQLGRR KAKSRQVLPT DLNDLICSNV