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1.A.17.4.14
Tmc4 (MBOAT7) of 712 aas and 10 TMSs (Mancina et al. 2016). Probably transports Ca2+, and other cations. May play a role in nonalcoholic fatty liver disease (NAFLD) (Sookoian et al. 2018), but it is not associated with a risk of hepatocellular carcinoma or persistent hepatitis B infection (Wang et al. 2021). Ibuprofen only minimally inhibited the taste response of the ENaC to NaCl, but it significantly inhibited the TMC4 response to NaCl with an IC50 at 1.45 mM. Thus, ibuprofen interferes with detection of salty taste via inhibition of TMC4 (Kasahara et al. 2021). This agrees with the fact that TMC4 is a chloride channel involved in high-concentration salt taste sensation (Kasahara et al. 2021). TMC4 is involved in pH and temperature-dependent modulation of salty taste (Kasahara et al. 2021).

Accession Number:Q7Z404
Protein Name:Transmembrane channel-like protein 4
Length:712
Molecular Weight:79208.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

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FASTA formatted sequence
1:	MEENPTLESE AWGSSRGWLA PREARGAPCS SPGPSLSSVL NELPSAATLR YRDPGVLPWG 
61:	ALEEEEEDGG RSRKAFTEVT QTELQDPHPS RELPWPMQAR RAHRQRNASR DQVVYGSGTK 
121:	TDRWARLLRR SKEKTKEGLR SLQPWAWTLK RIGGQFGAGT ESYFSLLRFL LLLNVLASVL 
181:	MACMTLLPTW LGGAPPGPPG PDISSPCGSY NPHSQGLVTF ATQLFNLLSG EGYLEWSPLF 
241:	YGFYPPRPRL AVTYLCWAFA VGLICLLLIL HRSVSGLKQT LLAESEALTS YSHRVFSAWD 
301:	FGLCGDVHVR LRQRIILYEL KVELEETVVR RQAAVRTLGQ QARVWLVRVL LNLLVVALLG 
361:	AAFYGVYWAT GCTVELQEMP LVQELPLLKL GVNYLPSIFI AGVNFVLPPV FKLIAPLEGY 
421:	TRSRQIVFIL LRTVFLRLAS LVVLLFSLWN QITCGGDSEA EDCKTCGYNY KQLPCWETVL 
481:	GQEMYKLLLF DLLTVLAVAL LIQFPRKLLC GLCPGALGRL AGTQEFQVPD EVLGLIYAQT 
541:	VVWVGSFFCP LLPLLNTVKF LLLFYLKKLT LFSTCSPAAR TFRASAANFF FPLVLLLGLA 
601:	ISSVPLLYSI FLIPPSKLCG PFRGQSSIWA QIPESISSLP ETTQNFLFFL GTQAFAVPLL 
661:	LISSILMAYT VALANSYGRL ISELKRQRQT EAQNKVFLAR RAVALTSTKP AL