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1.A.17.4.18
Transmembrane channel-like (TMC7) protein, of 723 aas and 11 TMSs. It probably transports  Ca2+, and other cations. It is important for oral tongue squamous cell carcinoma (OTSCC), with rapid local invasion and metastasis. The  long noncoding (lnc) RNA MIR4713HG is markedly upregulated in OTSCC. Upregulation of MIR4713HG promotes cell proliferation and metastasis (Jia et al. 2021). Micro RNA let7c5p physically binds MIR4713HG, and knockdown of let7c5p counteracts the effect of MIR4713HG on OTSCC. let7c5p exerted this role by affecting the expression level of TMC7 (Jia et al. 2021). TMC7 also affects other types (rectal and panrecatic) of cancer (Watanabe et al. 2014; Cheng et al. 2019), and may be associated with psychosis proneness (Ortega-Alonso et al. 2017).

Accession Number:AAH36205.1
Protein Name:AAH36205.1 Transmembrane channel-like 7 [Homo sapiens]
Length:724
Molecular Weight:
Species:Homo sapiens [9606]
Number of TMSs:11
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSESSGSALQ PGRPSRQQAV HPENLSLDSS CFSSPPVNFL QELPSYRSIA RRRTTVHSRD 
61:	KQSGTLLKPT DSYSSQLEDR IAENLSSHSL RNYALNISEK RRLRDIQETQ MKYLSEWDQW 
121:	KRYSSKSWKR FLEKAREMTT HLELWREDIR SIEGKFGTGI QSYFSFLRFL VLLNLVIFLI 
181:	IFMLVLLPVL LTKYKITNSS FVLIPFKDMD KQCTVYPVSS SGLIYFYSYI IDLLSGTGFL 
241:	EETSLFYGHY TIDEVKFQNF TYDLPLAYLL STIASLALSL LWIVKRSVEG FKINLIRSEE 
301:	HFQSYCNKIF AGWDFCITNR SMADLKHSSL RYELRADLEE ERMRQKIAER TSEETIRIYS 
361:	LRLFLNCIVL AVLGACFYAI YVATVFSQEH MKKEIDKMVF GENLFILYLP SIVITLANFI 
421:	TPMIFAKIIR YEDYSPGFEI RLTILRCVFM RLATICVLVF TLGSKITSCD DDTCDLCGYN 
481:	QKLYPCWETQ VGQEMYKLMI FDFIIILAVT LFVDFPRKLL VTYCSSCKLI QCWGQQEFAI 
541:	PDNVLGIVYG QTICWIGAFF SPLLPAIATL KFIIIFYVKE WSLLYTCRPS PRPFRASNSN 
601:	FFFLLVLLIG LCLAIIPLTI SISRIPSSKA CGPFTNFNTT WEVIPKTVST FPSSLQSFIH 
661:	GVTSEAFAVP FFMIICLIMF YFIALAGAHK RVVIQLREQL SLESRDKCYL IQKLTEAQRD 
721:	MRN