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1.A.17.4.19 TMC-1 of 1285 aas and 9 TMSs in a 2 + 3 + 4 TMS arrangement. Mutants show strong defects in the avoidance of NaCl concentrations above 100 mM (Chatzigeorgiou et al. 2013). Tmc-1 is a sodium-sensitive channel required for salt chemosensation in C. elegans (Chatzigeorgiou et al. 2013).
Accession Number:	Q11069
Protein Name:	Transmembrane channel-like protein 2
Length:	1203
Molecular Weight:	136060.00
Species:	Caenorhabditis elegans [6239]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	sodium(1+)

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MPKSGAHQPL VRHDTDDGGE TGQSVKSLAD VSEEEIDSRM SRRSSVIADL LSLFRRSSSV 
61:	LVRPHTRLGN PNFDDDDDEF DEEDDKEASK DRILKKIQQK KEIIQKLRGQ PWYMKRKRRT 
121:	LKVAQKHLQQ QEAKVSKARL YKAEAGRRLT QASRWLDNLK IYLIPWEAKI RKIESHFGSV 
181:	VSSYFTFHRW VLGVNITITF IMCMFVVIPE WLADSRTQFG DDRYNKTKAI KVMPPAVRAR 
241:	ADELSTVWDF GGYFQYSLLF YGFYSKETFF GETIKYRVPV AYFFCNIFIL GFSLFIILRK 
301:	MAANNRRGTL SSGKTQQYLF NWKAFTGWDY TIGNPETAGN VYMANVIKFR EAINDDKQKP 
361:	SDKHPWIRFV ARVLTNLFIC AMYVFSIWAI MQCGTLKGEH FFAQNATAIT ISLITLVFPN 
421:	IFDLLGKIEK LHPRNALRFQ LGRVLVLYIL NYYTLIYSLM LQLEHLQKEK NASDNPISAL 
481:	GHPGDAIGRT IRETVLPRYP VDNNPHTYYS YAPVTTTPIP ATSSWTTVLP DFGPFGVYNP 
541:	KASVTKDDTV FSSPVVETHM FGPNSDWNET TVNAASPTGA TTRASLRMSQ GGLCWETIIG 
601:	QEITKLVTMD LYMTVASIFL IDFLRGLACR YLNLYWPWDL ERTFPEYGEF KVAENVLHLV 
661:	NNQGMIWLGL FFVPLLPMLN NIKLIILMYI RGWAAMTCNV PASQIFRASR SSNFFFALLI 
721:	LFLFLCTLPV GFVIASKTPS KSCGPFGNQS FFYSVITDVL HENLDKTLVN GIKYSLSPGI 
781:	IIPVLVLLSL VIYFLIAMVT GLSQANQDLS FQLMVERTEE KKKIFELAGG KKKKSKDNTF 
841:	GKQKPKQLLP PPTKGVSSDD DSQHNRSTAK SVSGRQFVPS LGSVSEVDHS TGEEQSSDSE 
901:	STTSSLPPKL SLRQRFLVCI GWADPNKYGR HDDIEMEEGG GRLRELSTGS ETDSDDEDSE 
961:	KSNRDMSYRT AIQSFDQNSQ SASASSSKST TTAPSNSEMR IEITENPLHT YITPLRIEKK 
1021:	SSASSSSSSH QPSSSIEKQA ARRLLQPIST THNIRYGVAT VENSSQDPTR PPSTDDSLGD 
1081:	PALHEPLWAN LNPHSSYTSA MMSPIMNEVM SNDETTDDEK GRLIPDRPPI PHSPRELKRL 
1141:	KREKDQQSES GSKPSTPRPP RFRISMSPPR KPPSEKNDSD SSNRKYEMRV EKSPKKPKKS 
1201:	DND

1.A.17.4.19
TMC-1 of 1285 aas and 9 TMSs in a 2 + 3 + 4 TMS arrangement. Mutants show strong defects in the avoidance of NaCl concentrations above 100 mM (Chatzigeorgiou et al. 2013). Tmc-1 is a sodium-sensitive channel required for salt chemosensation in C. elegans (Chatzigeorgiou et al. 2013).

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1.A.17.4.19TMC-1 of 1285 aas and 9 TMSs in a 2 + 3 + 4 TMS arrangement. Mutants show strong defects in the avoidance of NaCl concentrations above 100 mM (Chatzigeorgiou et al. 2013). Tmc-1 is a sodium-sensitive channel required for salt chemosensation in C. elegans (Chatzigeorgiou et al. 2013).

Cross database links:

External Searches:

Analyze:

1.A.17.4.19
TMC-1 of 1285 aas and 9 TMSs in a 2 + 3 + 4 TMS arrangement. Mutants show strong defects in the avoidance of NaCl concentrations above 100 mM (Chatzigeorgiou et al. 2013). Tmc-1 is a sodium-sensitive channel required for salt chemosensation in C. elegans (Chatzigeorgiou et al. 2013).