1.A.17.4.2
Transmembrane channel-like protein-B, Tmc8 (EVER2). It occurs in the endoplasmic reticulum where it functions to release Ca2+ and Zn2+ and supresses Cl- currents (Sirianant et al. 2014). The functional variant, rs7208422 of the TMC8 gene, has been suggested to have a high impact on susceptibility to beta-papillomaviruses and their oncogenic potential and to also have an influence on alpha-type HPV-related disease (Stoehr et al. 2021).
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| Accession Number: | Q7TN58 |
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| Protein Name: | Transmembrane channel-like protein 8 |
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| Length: | 722 |
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| Molecular Weight: | 82329.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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| Entrez Gene ID: |
217356
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| Pfam: |
PF07810
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| KEGG: |
mmu:217356
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[1] “Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.” Kurima K. et.al. 12906855
[2] “TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.” Keresztes G. et.al. 12812529
[3] “The transcriptional landscape of the mammalian genome.” Carninci P. et.al. 16141072
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1: MFRQWSVQSG PAPRRPESQA ASEELWEQEV ERLCASRTPV RMLPYAMADK RFIRELREPE
61: GVKTTFWQRW HRPRRVARQH LREAEQRLAR GFGLWEGALY EIGGLFGTGI QSYFTFLRFL
121: LLLNLLTMLL TACFVLLPLV WLRPPELGPA LKLRLQCSSS PLPQSDIPRF HNPLWNILTG
181: RAFNNTYLFY GAYRAGPESS SEYSIRLAYL LSPMVCLLLC FCGILQRMAE GLPQQTLLGQ
241: RYRTPLSAKV FSSWDFCIRV WEAATIKKHE ISNELKMELE EGRRVELAQQ QTRAQKACRL
301: LTYLRTNILI VLLVVGAISA IFWATKYSQD NKEESLFLVL QYLPPGVISL VNFLGPQLFT
361: VLIQLENYPP GTEVNLTLIW CVVLKLASLG MFSFSLGQTV LCIGRNKTSC ESYGYNACDY
421: QCWENSVGEE LYKLIIFNFL LTVAFAFLVS LPRRLLVERF SGWFWTWLDR EEFLVPKNVL
481: DIVAAQTVTW MGLFYCPLLP LLNSVFLFLT FYIKKYTLLR NSRASPRRFR ASSSTFFFHL
541: VLLLGLLLAA VPLAYVISST HSSWDCGLFT NYSAPWQVVP ELVALQLPLP SQRALRYLSS
601: HAFSFPLLIL LSIVLTVCIS QSRANARAIQ GLRKQLVWQV QEKWHLVDDL SRLLPELSPE
661: PGSPHSRASR PRSFCPGFPC PGSPGPRTPR LAPSNRLSSS SLGAPSASVP ASRFHFPSRT
721: EL