1.A.17.4.9
Tmc receptor/channel of 1932 aas and about 10 TMSs. Plays a role in Drosophila proprioception and the
sensory control of larval locomotion (Guo et al. 2016). These Tmc channels may be activated by membrane curvature in dendrites that are exposed to strain, possibly explaining how different cellular systems rely on a common molecular pathway for mechanosensory responses (He et al. 2019).
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| Accession Number: | M9NDN5 |
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| Protein Name: | CG3280 |
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| Length: | 1932 |
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| Molecular Weight: | 216669.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 10 |
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| Substrate |
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1: MQSSADAKRE FYKGQRGRRA ASQEDHRSYE LNDFPLQNQS SDAESCHQEP HFAHQRSPGI
61: GFDEDGGGGD IDDEESYTIS VSAIMQRRAS VRGYRGKRGS RSSRRASSPM DHVLDSVERR
121: RSSVYTTSSE EGTNQESTQE QIFENIRLHK EVIQSVKLQP WPIRKKLKLV RQAKTYVARH
181: EGALQERFAM SRSTRDLWAR FKILMAARWR HWKRETASFL TVLIPWELRI KEIESHFGSG
241: VASYFTFLRW LMWVNIMIAI PLVAFVIGPE YFATKHGETD PRKRMSDPEA RVAGNLFTFW
301: EFEGYLKYSP MFYGYYSSTS GISTSGYKLP LAYFLTAVLV YIYSFVATLR KMAENSRNSK
361: LSSKDDECVF SWKLFTGWDF MIGHAETAHN RIASVVVGFK EALLEEAEKK KDNRNWRVIL
421: QRILVNILVM GLLGLSGATV VLLVNHSEDL AKHDNWLSRN AVNVTMTLLS FFLPMIFEAL
481: GLFENWHPRQ QLRLQLARIM ILNMLNLYSL MFSFIYKINS KEKPLQMLKL ENETNTMELK
541: NLLSSIEALR AMTPTTSLYG ESTSDGLFDD STSTATWGED GGGLFSTTAA AALISTTVQR
601: LKCYNMTVKC SKLRRNIISG KHLATTLMVL NLTTPAMVPP TLPTTLPTTF PTTLPTTLPT
661: TLPTALPTTL PTTLPTTLPS TLATTTATTS SIWSTTEETS PTTTTTSPWT TLPPSTTTTE
721: ATTTTERATT TTEATSTTTL KITTAEINST LSDTTKPLGK SIDTEIPNST TNSATLSTIP
781: ATLNTTNLPL NSTTKLTTTT STEKPQGEDN FIYTTGEDEG SYDYGSDSTS DAPDNNSYSD
841: ITDYSSEPSE IEDFDEQEST DQADDPLAKV LEQLDENETK GRRKRALAES PFFTSKYSRR
901: HRNESAVSAG QPRETTESVN ATPSRWPFNW ASFRQTTPRT TTTRRVPSGI LTKEEWERLR
961: RLRGRITTTT STSTTSTTTR RPRWRYRTTT TELTSTTEEE SSTTESSTDS SSPGSTTNAF
1021: DSSSSTTEED EYTTTEGSEN RPYYVGYVDI SEMGSTIYYD GDSEFLEECV ITICPKGDDF
1081: FGSTTESPDS TTQSSDSKQL TTVKLTPLER KQKRLKEVQL AIKQIQTNLT TMCWETSLGQ
1141: ELSKVIVFDG LMSIVAPLCI DFLRALFVRY VNQNWCWDME KTFPQYGDFK IAENILTLIN
1201: NQGQVWMGIF FSPGLVLINL VKLMIMMYFR SWIVLTCNVP HEVVFKASKS NNFYLSLLLT
1261: MLFLCVLPVG YAIVWLRPSW HCGPFSEYNR IAEFITNTTR NALPKQLHEP LDYLTSSSTV
1321: IPLLLLLILI IYYLVSLTGA LREANQDLRT QLQKEREEER KKIFKVPEVK QAEPTATTLT
1381: NRWRKVLEAS SPVTPTQPPD FDTEEYKNQA RKELISRIMK KALRKGSATS DEDSFVRRDD
1441: DDTDTEHQDS LPHDEEAKDK RFGLSRLQQI RRTRKPSLVD IVQIAKQERA RAGSIVAGTS
1501: SSGTGNFPIK ETHPKSRFKV EKHERKDRGS MKDKKDTRHR QSPQQQQQPP PYESPKDNEH
1561: DPDTNSRIVS ASLLRRHKEQ AEGEEPPTTP DAPQTPNSPV EPVEQALEES TPETPTLAKS
1621: KFHIVDEKKP PPHEVEDKPL PTPKESGSGG GSLGKFKFRK HKFKSNNVAA VKPEPEVFKF
1681: DERSVERSSD VPATHAAEYL NNEPSGTEEQ DRSLPSPTPS QGQGHHQRQL SVLSRQGRKK
1741: IGNLLALVRE AVNLKKDDVE QAGSDESPGP TTPTYLAYTP PPPPSVLSSV SSSTALEMPP
1801: TPEPESPTPS APLHFGSSTS SRAPSKPPKP PMVPASATAP TATMDDLEEL DTAGPITFPR
1861: RSDSHRRRTM RQDSQSSIWS DNIPTITIST TGSDECIVDA AAPQNGLPDP RSASPEPTVN
1921: IIRIDIENEH EK