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1.A.17.5.12
The osmosensitive calcium-permeable cation channel, CSC1 or Tmem63c, of 806 aas and ~10 TMSs.  It is activated by hyperosmolarity and Ca2+ (Hou et al. 2014). Tmem63c is a potential pro-survival factor in angiotensin II-treated human podocytes (Eisenreich et al. 2020). It is regulated by microRNA-564 and transforming growth factor beta (TGFβ) in human renal cells, and is therefore a potential target for albuminuria development (Orphal et al. 2020).  

Accession Number:Q9P1W3
Protein Name:Calcium permeable stress-gated cation channel 1
Length:806
Molecular Weight:93317.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSASPDDLST GGRLQNMTVD ECFQSRNTVL QGQPFGGVPT VLCLNIALWV LVLVVYSFLR 
61:	KAAWDYGRLA LLIHNDSLTS LIYGEQSEKT SPSETSLEME RRDKGFCSWF FNSITMKDED 
121:	LINKCGDDAR IYIVFQYHLI IFVLIICIPS LGIILPINYT GSVLDWSSHF ARTTIVNVST 
181:	ESKLLWLHSL LSFFYFITNF MFMAHHCLGF APRNSQKVTR TLMITYVPKD IEDPELIIKH 
241:	FHEAYPGSVV TRVHFCYDVR NLIDLDDQRR HAMRGRLFYT AKAKKTGKVM IRIHPCARLC 
301:	FCKCWTCFKE VDAEQYYSEL EEQLTDEFNA ELNRVPLKRL DLIFVTFQDS RMAKRVRKDY 
361:	KYVQCGVQPQ QSSVTTIVKS YYWRVTMAPH PKDIIWKHLS VRRFFWWARF IAINTFLFFL 
421:	FFFLTTPAII MNTIDMYNVT RPIEKLQNPI VTQFFPSVML WGFTVILPLI VYFSAFLEAH 
481:	WTRSSQNLVM VHKCYIFLVF MVVILPSMGL TSLDVFLRWL FDIYYLEQAS IRFQCVFLPD 
541:	NGAFFVNYVI TAALLGTGME LLRLGSLFCY STRLFFSRSE PERVNIRKNQ AIDFQFGREY 
601:	AWMMNVFSVV MAYSITCPII VPFGLLYLCM KHLTDRYNMY YSFAPTKLNE QIHMAAVSQA 
661:	IFAPLLGLFW MLFFSILRLG SLHAITIFSL STLLIAMVIA FVGIFLGKLR MVADYEPEEE 
721:	EIQTVFDMEP SSTSSTPTSL LYVATVLQEP ELNLTPASSP ARHTYGTMNN QPEEGEEESG 
781:	LRGFARELDS AQFQEGLELE GQNQYH