1.A.17.5.23
DUF221 domain-containing CSC1 protein (AN2880 gene) of 1033 aas and 11 TMSs. The calF7 mutation in Aspergillus nidulans causes hypersensitivity to the cell wall compromising agents Calcofluor White (CFW) and Congo Red. Hill et al. 2023 demonstrated that the calF7 mutation resides in gene AN2880, encoding a member of the OSCA/TMEM63 family of transmembrane glycoproteins. GFP-tagged wild type CalF localizes principally to the Spitzenkorper and the plasma membrane at growing tips and forming septa. However, both septation and hyphal morphology appear to be normal in calF7 and AN2880 deletion strains, indicating that any role played by CalF in normal hyphal growth and cytokinesis is dispensable (Hill et al. 2023).
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| Accession Number: | XP_660484.1 |
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| Protein Name: | XP_660484.1 protein calF [Aspergillus nidulans FGSC A4] |
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| Length: | 1034 |
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| Molecular Weight: | |
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| Species: | Aspergillus nidulans FGSC A4 [227321] |
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| Number of TMSs: | 11 |
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| Substrate |
calcium(2+) |
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1: MDYRALWRRD GAEEFLKLIQ DPFKSAFQTN AVWASLATSA VVAIVLALLF SLFRPRHTLV
61: YAPKVKHADR KHAPPPVGKG LFAWIKPVIR TKEAELVDCV GLDATIFIRF TKMCRNIFIF
121: LSIIGCGVMI PVNLTQSQNT DGATAFVVMT PLYVKVNAIW SQVVCAWAFN IIITFFLWRN
181: YKAVLALRRR YFESSDYQRS LHARTLMITD IPPDLRTDEG FLRLTDELNP TAALPRSSVG
241: RNVKGLPKLI KEHEELVRKL ESVLAKYLKN PDRLPPSRPT MRPPRGHRDE DGSGKVDAID
301: YLTDRIQRLE EEIRHVRASI DKRNAMPYGF VSWDKIEHAH AVAYVARNKH PRGTTIRLAT
361: RPHDLIWENL SLSKSARKWK AFVMFLWVTA LTVVWIAPNA LIAVFLSNLS NLGSVWPAFQ
421: TELDRNRKVW AAVQGILSPA VTSLFYLLLP IIFRRLSART GDATKTLREQ HVLRHLYSFF
481: VFNNLIVFSL FSAVWTFIAA VIDLKNKNED PWQAVQDGQF YIKAFSAMCN VSPFWVTYLL
541: QRNMGAAIDL VQFVHLIWVW FAKTFLAPTP RQTIEWTAPP AFDYASYYNY FLYYSTIAIC
601: FATLQPIVLP VTALYFGLDA MMKKYMLMYI FVTKNESGGQ FWRVLFNRVV FAAILSNVII
661: GLVAKARGTW NMVYCVVPLP FLMLLFKWYC MRTFDDDCTY YNKANLSDTE ALAASKSSKS
721: AGDRLSSKFG HPALFKPLIT PMVHAKAADA LKQIYRGRLG GNEAEGDYSD IVMDPMMKSQ
781: PGKTMPDTSA PFEVVPEHHL DFAYYKDRAD FQEEFGGGIY GRPEDLMTER SHTPRSALGD
841: WSPTSSRAPS PAPSVPSLPM LQPEAYDPRL NQGMHPVFRP PPFRTGSGMS RGLYQHQNES
901: ETELLGQVQQ PAGVSMQPWR PGGGYGPVDQ DDHAFTSYEQ YLVSIVPENY TLAVRQQPQA
961: PGACLPITGL GRSLFPDNTR TTDSRSLGSP SATVARPELY DAVAISNSRC LYKPALCKLN
1021: QQPIRRCLVQ HLN