1.A.17.5.24
CSC1-like protein ERD4 of 724 aas and 11 or 10 TMSs in a 3 + 7 or 8 TMS arrangement. It acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca2+ ions, and is a
mechanosensitive ion channel that converts mechanical stimuli into a flow of ions (Zhang et al. 2018).
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| Accession Number: | Q9C8G5 |
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| Protein Name: | CSC1-like protein ERD4 |
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| Length: | 724 |
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| Molecular Weight: | 81935.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
inorganic cation, calcium ion |
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1: MEFGSFLVSL GTSFVIFVIL MLLFTWLSRK SGNAPIYYPN RILKGLEPWE GTSLTRNPFA
61: WMREALTSSE QDVVNLSGVD TAVHFVFLST VLGIFACSSL LLLPTLLPLA ATDNNIKNTK
121: NATDTTSKGT FSQLDNLSMA NITKKSSRLW AFLGAVYWIS LVTYFFLWKA YKHVSSLRAQ
181: ALMSADVKPE QFAILVRDMP APPDGQTQKE FIDSYFREIY PETFYRSLVA TENSKVNKIW
241: EKLEGYKKKL ARAEAILAAT NNRPTNKTGF CGLVGKQVDS IEYYTELINE SVAKLETEQK
301: AVLAEKQQTA AVVFFTTRVA AASAAQSLHC QMVDKWTVTE APEPRQLLWQ NLNIKLFSRI
361: IRQYFIYFFV AVTILFYMIP IAFVSAITTL KNLQRIIPFI KPVVEITAIR TVLESFLPQI
421: ALIVFLAMLP KLLLFLSKAE GIPSQSHAIR AASGKYFYFS VFNVFIGVTL AGTLFNTVKD
481: IAKNPKLDMI INLLATSLPK SATFFLTYVA LKFFIGYGLE LSRIIPLIIF HLKKKYLCKT
541: EAEVKEAWYP GDLSYATRVP GDMLILTITF CYSVIAPLIL IFGITYFGLG WLVLRNQALK
601: VYVPSYESYG RMWPHIHQRI LAALFLFQVV MFGYLGAKTF FYTALVIPLI ITSLIFGYVC
661: RQKFYGGFEH TALEVACREL KQSPDLEEIF RAYIPHSLSS HKPEEHEFKG AMSRYQDFNA
721: IAGV