1.A.17.5.3
Transmembrane protein 63B of 832 aas and about 10 TMSs with a DUF221 domain. It acts as an osmosensitive calcium-permeable cation channel, and is a mechanosensitive ion channel that converts mechanical stimuli into a flow of ions. It is a stretch-activated ion channel that associates with developmental and epileptic encephalopathies as well as progressive neurodegeneration (Vetro et al. 2023).
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| Accession Number: | Q5T3F8 |
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| Protein Name: | Transmembrane protein 63B |
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| Length: | 832 |
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| Molecular Weight: | 94958.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MLPFLLATLG TTALNNSNPK DYCYSARIRS TVLQGLPFGG VPTVLALDFM CFLALLFLFS
61: ILRKVAWDYG RLALVTDADR LRRQERDRVE QEYVASAMHG DSHDRYERLT SVSSSVDFDQ
121: RDNGFCSWLT AIFRIKDDEI RDKCGGDAVH YLSFQRHIIG LLVVVGVLSV GIVLPVNFSG
181: DLLENNAYSF GRTTIANLKS GNNLLWLHTS FAFLYLLLTV YSMRRHTSKM RYKEDDLVKR
241: TLFINGISKY AESEKIKKHF EEAYPNCTVL EARPCYNVAR LMFLDAERKK AERGKLYFTN
301: LQSKENVPTM INPKPCGHLC CCVVRGCEQV EAIEYYTKLE QKLKEDYKRE KEKVNEKPLG
361: MAFVTFHNET ITAIILKDFN VCKCQGCTCR GEPRPSSCSE SLHISNWTVS YAPDPQNIYW
421: EHLSIRGFIW WLRCLVINVV LFILLFFLTT PAIIITTMDK FNVTKPVEYL NNPIITQFFP
481: TLLLWCFSAL LPTIVYYSAF FEAHWTRSGE NRTTMHKCYT FLIFMVLLLP SLGLSSLDLF
541: FRWLFDKKFL AEAAIRFECV FLPDNGAFFV NYVIASAFIG NAMDLLRIPG LLMYMIRLCL
601: ARSAAERRNV KRHQAYEFQF GAAYAWMMCV FTVVMTYSIT CPIIVPFGLM YMLLKHLVDR
661: YNLYYAYLPA KLDKKIHSGA VNQVVAAPIL CLFWLLFFST MRTGFLAPTS MFTFVVLVIT
721: IVICLCHVCF GHFKYLSAHN YKIEHTETDT VDPRSNGRPP TAAAVPKSAK YIAQVLQDSE
781: VDGDGDGAPG SSGDEPPSSS SQDEELLMPP DALTDTDFQS CEDSLIENEI HQ