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1.A.2.1.13
ATP-sensitive inward rectifying K+ channel 8, KCNJ8 or Kir6.1. It acts with Sur2B (3.A.1.208.23). Channel activity is inhibited in oxidative stress via S-glutathionylation (Yang et al., 2011). Oxidative sensitivity is dependent on Cys176 (Yang et al., 2011).  These proteins comprise part of a glucose sensing mechanism (Rufino et al. 2013). It may play a role in limb wound repair and regeneration (Zhang et al. 2020). It is inhibited by glibenclamide (glyburide), an antidiabetic sulfonylurea used in the treatment of type II diabetes (Fernandes et al. 2004). Gain-of-function mutations in Kir6.1 and regulatory (SUR1) subunits of KATP channels can cause human neonatal diabetes mellitus by altering insulin secretion (Remedi et al. 2017).

Accession Number:Q15842
Protein Name:ATP-sensitive inward rectifier potassium channel 8
Length:424
Molecular Weight:47968.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Drugbank: Drugbank Link   

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLARKSIIPE EYVLARIAAE NLRKPRIRDR LPKARFIAKS GACNLAHKNI REQGRFLQDI 
61:	FTTLVDLKWR HTLVIFTMSF LCSWLLFAIM WWLVAFAHGD IYAYMEKSGM EKSGLESTVC 
121:	VTNVRSFTSA FLFSIEVQVT IGFGGRMMTE ECPLAITVLI LQNIVGLIIN AVMLGCIFMK 
181:	TAQAHRRAET LIFSRHAVIA VRNGKLCFMF RVGDLRKSMI ISASVRIQVV KKTTTPEGEV 
241:	VPIHQLDIPV DNPIESNNIF LVAPLIICHV IDKRSPLYDI SATDLANQDL EVIVILEGVV 
301:	ETTGITTQAR TSYIAEEIQW GHRFVSIVTE EEGVYSVDYS KFGNTVKVAA PRCSARELDE 
361:	KPSILIQTLQ KSELSHQNSL RKRNSMRRNN SMRRNNSIRR NNSSLMVPKV QFMTPEGNQN 
421:	TSES