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1.A.20.2.1
BCL2/Adenovirus E1B interacting protein, NIP3

Accession Number:Q09969
Protein Name:NIP3 homolog
Length:210
Molecular Weight:23577.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Single-pass membrane protein2
Substrate small molecules

Cross database links:

HEGENOM: HBG388627
DIP: DIP-26299N
Entrez Gene ID: 181053   
Pfam: PF06553   
KEGG: cel:C14F5.1   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031966 C:mitochondrial membrane
GO:0002020 F:protease binding
GO:0042803 F:protein homodimerization activity
GO:0003700 F:sequence-specific DNA binding transcription factor activity
GO:0006915 P:apoptosis
GO:0008340 P:determination of adult lifespan
GO:0006917 P:induction of apoptosis
GO:0051726 P:regulation of cell cycle

References (5)

[1] “Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog.”  Yasuda M.et.al.   9824163
[2] “The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism.”  Cizeau J.et.al.   11114722
[3] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[4] “Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.”  Oh S.W.et.al.   16380712
[5] “DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.”  Pinkston-Gosse J.et.al.   17934462

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MLDIKRKINF ASGEKTDESV QPQQQTEQSS AQQTTPSAKA VSNPFITPLT ESTPGMSESW 
61:	VELAPSRTSL CSSVDINMVI IDEKDKDSRL SPVSIAQSPH VEFESLEQVK YKLVREMLPP 
121:	GKNTDWIWDW SSRPENTPPK TVRMVQYGSN LTTPPNSPEP ELYQYLPCES DSLFNVRVVF 
181:	GFLVTNIFSF VVGAAVGFAV CRKLIKHHRQ