| |
---|---|
Accession Number: | Q16611 |
Protein Name: | Bcl-2 homologous antagonist/killer |
Length: | 211 |
Molecular Weight: | 23409.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 2 |
Location1 / Topology2 / Orientation3: | Membrane1 / Single-pass membrane protein2 |
Substrate | molecule, macromolecule, cytochrome c |
Cross database links:
DIP: | DIP-935N |
---|---|
RefSeq: | NP_001179.1 |
Entrez Gene ID: | 578 |
Pfam: | PF00452 |
OMIM: |
600516 gene |
KEGG: | hsa:578 |
Gene Ontology
GO:0005741
C:mitochondrial outer membrane
GO:0046930
C:pore complex
GO:0042802
F:identical protein binding
GO:0046872
F:metal ion binding
GO:0046982
F:protein heterodimerization activity
GO:0010248
P:establishment or maintenance of transmembra...
GO:0006917
P:induction of apoptosis
GO:0046902
P:regulation of mitochondrial membrane permea...
GO:0051881
P:regulation of mitochondrial membrane potential
GO:0043497
P:regulation of protein heterodimerization ac...
GO:0043496
P:regulation of protein homodimerization acti...
GO:0001836
P:release of cytochrome c from mitochondria
| |
References (9)[1] “Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K.” Farrow S.N.et.al. 7715729 [2] “Induction of apoptosis by the Bcl-2 homologue Bak.” Chittenden T.et.al. 7715730 [3] “Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak.” Kiefer M.C.et.al. 7715731 [4] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 | |
Structure: | |
[...more] |
External Searches:
|
Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
|
1: MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQEQEAE GVAAPADPEM 61: VTLPLQPSST MGQVGRQLAI IGDDINRRYD SEFQTMLQHL QPTAENAYEY FTKIATSLFE 121: SGINWGRVVA LLGFGYRLAL HVYQHGLTGF LGQVTRFVVD FMLHHCIARW IAQRGGWVAA 181: LNLGNGPILN VLVVLGVVLL GQFVVRRFFK S