1.A.21.1.7
Pore-forming Bcl-2-related ovarian killer protein, Bok (BokL, Bcl2L9) of 212 aas and 2 or more predicted TMSs.  It is an apoptosis regulator that functions through different apoptotic signaling pathways (Einsele-Scholz et al. 2016, Yakovlev et al. 2004, Jääskeläinen et al. 2010). The transmembrane-domain contributes to the pro-apoptotic function and interactions of Bok with other proteins (Stehle et al. 2018). Bok binds to a largely disordered loop in the coupling domain of type 1 inositol 1,4,5-trisphosphate receptors, and high affinity binding is mediated by multivalent interactions (Szczesniak et al. 2021).