TCDB » SEARCH

« See all members of the family

1.A.22.1.2 Large mechanosensitive ion channel of 151 aas and 2 TMSs. The 3-D structure is known, and it may reflect a nearly closed rather than fully closed state. Modeling support a clockwise rotation of the pore-forming first TMS promotes gating (Bartlett et al. 2004).
Accession Number:	P0A5K8
Protein Name:	Large-conductance mechanosensitive channel MscL aka RV0985C
Length:	151
Molecular Weight:	16023.00
Species:	Mycobacterium tuberculosis [1773]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	ion

Structure:
RefSeq:	NP_215500.1 NP_335447.1
Entrez Gene ID:	885368 925186
Pfam:	PF01741
KEGG:	mtc:MT1013 mtu:Rv0985c
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005216 F:ion channel activity GO:0006811 P:ion transport
References (2) [1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.” Cole S.T.et.al. 9634230 [2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.” Fleischmann R.D.et.al. 12218036
2oar

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MLKGFKEFLA RGNIVDLAVA VVIGTAFTAL VTKFTDSIIT PLINRIGVNA QSDVGILRIG 
61:	IGGGQTIDLN VLLSAAINFF LIAFAVYFLV VLPYNTLRKK GEVEQPGDTQ VVLLTEIRDL 
121:	LAQTNGDSPG RHGGRGTPSP TDGPRASTES Q

1.A.22.1.2
Large mechanosensitive ion channel of 151 aas and 2 TMSs. The 3-D structure is known, and it may reflect a nearly closed rather than fully closed state. Modeling support a clockwise rotation of the pore-forming first TMS promotes gating (Bartlett et al. 2004).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.A.22.1.2Large mechanosensitive ion channel of 151 aas and 2 TMSs. The 3-D structure is known, and it may reflect a nearly closed rather than fully closed state. Modeling support a clockwise rotation of the pore-forming first TMS promotes gating (Bartlett et al. 2004).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.A.22.1.2
Large mechanosensitive ion channel of 151 aas and 2 TMSs. The 3-D structure is known, and it may reflect a nearly closed rather than fully closed state. Modeling support a clockwise rotation of the pore-forming first TMS promotes gating (Bartlett et al. 2004).