1.A.27.1.7
FXYD7 of 80 aas and 1 TMS. The TMS mediates the complex interactions with the Na,K-ATPase (Li et al. 2005). The brain-specific FXYD7 is a member of the FXYD family that associates with the alpha1-beta1 Na,K-ATPase isozyme and induces a 2-fold decrease in its apparent K⁺ affinity. In contrast to FXYD2 and FXYD4, the conserved FXYD motif in the extracytoplasmic domain is not involved in the association of FXYD7 with the Na,K-ATPase. The conserved Gly40 and Gly29, located on the same face of the TMS, were implicated in the association with and the regulation of Na,K-ATPase (Crambert et al. 2004). The C-terminal valine residue is involved in  ER export of FXYD7. FXYDs are a vertebrate innovation and an important site of hormonal action (Pirkmajer and Chibalin 2019).