1.A.27.1.8
Phospholemman, FXYD1 or PLM of 92 aas and 1 TMS.  See 1.A.27.1.1 for details for the dog ortholog. Palmitoylation affects the regulation of cardiac electrophysiology, by modifying the sodium-calcium exchanger, phospholemman and the cardiac sodium pump, as well as the voltage-gated sodium channel (Essandoh et al. 2020). Palmitoylation of PLM inhibits the Na⁺ K⁺-ATPase while phosphorylation reverses this inhibition. The conserved FXYD motif is found in this protein at residues 29-32 (Cheung et al. 2013).  Dreammist in zebrafish, a neuronal-expressed phospholemman homolog, is important for regulating sleep-wake behaviour (Barlow et al. 2023).