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1.A.27.3.1 FXYD5 regulator of Na,K⁺-ATPase and ion channel activities of 178 aas and 1 C-terminal TMS. FXYD5 interacts directly with the Na⁺,K⁺-ATPase via their TMSs to affect the V_max of the latter, and residues involved have been identified (Lubarski et al. 2007).
Accession Number:	Q96DB9
Protein Name:	Dysadherin aka FxyD5
Length:	178
Molecular Weight:	19453.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Membrane¹ / Single-pass type I membrane protein²
Substrate	ion

RefSeq:	NP_001158077.1 NP_054883.3 NP_659003.1
Entrez Gene ID:	53827
Pfam:	PF02038
OMIM:	606669 gene
KEGG:	hsa:53827
Gene Ontology GO:0016021 C:integral to membrane GO:0003779 F:actin binding GO:0045296 F:cadherin binding GO:0005216 F:ion channel activity GO:0006811 P:ion transport GO:0030033 P:microvillus assembly GO:0046588 P:negative regulation of calcium-dependent ce...
References (6) [1] “A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP11/PLM/MAT8 family of transmembrane proteins.” Omasa T.et.al. 11342114 [2] “Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.” Ino Y.et.al. 11756660 [3] “Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.” Zhang Q.-H.et.al. 11042152 [4] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.” Clark H.F.et.al. 12975309 [5] “The DNA sequence and biology of human chromosome 19.” Grimwood J.et.al. 15057824 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MSPSGRLCLL TIVGLILPTR GQTLKDTTSS SSADSTIMDI QVPTRAPDAV YTELQPTSPT 
61:	PTWPADETPQ PQTQTQQLEG TDGPLVTDPE THKSTKAAHP TDDTTTLSER PSPSTDVQTD 
121:	PQTLKPSGFH EDDPFFYDEH TLRKRGLLVA AVLFITGIII LTSGKCRQLS RLCRNHCR

1.A.27.3.1
FXYD5 regulator of Na,K⁺-ATPase and ion channel activities of 178 aas and 1 C-terminal TMS. FXYD5 interacts directly with the Na⁺,K⁺-ATPase via their TMSs to affect the V_max of the latter, and residues involved have been identified (Lubarski et al. 2007).

Cross database links:

Gene Ontology

References (6)

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1.A.27.3.1FXYD5 regulator of Na,K+-ATPase and ion channel activities of 178 aas and 1 C-terminal TMS. FXYD5 interacts directly with the Na+,K+-ATPase via their TMSs to affect the Vmax of the latter, and residues involved have been identified (Lubarski et al. 2007).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

1.A.27.3.1
FXYD5 regulator of Na,K⁺-ATPase and ion channel activities of 178 aas and 1 C-terminal TMS. FXYD5 interacts directly with the Na⁺,K⁺-ATPase via their TMSs to affect the V_max of the latter, and residues involved have been identified (Lubarski et al. 2007).