1.A.28.1.4 THe urea transporter channel protein of 337 aas and 11 TMSs in an apparent 6 + 5 TMS arrangement. The 3-d structure (2.3 Å resolution) is available (Levin et al., 2009). Urea binding and flux as well as dimethylurea (DMU) transport have been modeled (Zhang et al. 2017).
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Accession Number: | A1VEP3 |
Protein Name: | Urea transporter |
Length: | 337 |
Molecular Weight: | 35757.00 |
Species: | Desulfovibrio vulgaris subsp. vulgaris (strain DP4) [391774] |
Number of TMSs: | 11 |
Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
Substrate |
urea, N,N'-dimethylurea |
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1: MFGEQLLKNP LIEFCDSVCR GCGQVMFQNN TVTGLLFFAG IFYNSTTLGV CAVLGTAAST
61: LTAQLLGVDK PLVRAGLFGF NGTLAGIALP FFFNYEPAML GYVALNGAFT TIIMASLLNF
121: LGKWGVPALT APFVLATWLL MFGVYKLSLF HPGALIAPAL PSVAGLADMG TVTGRTFMEG
181: LFKGVGEVMF QDNIVTGVIF VVAILVNSRI SALFAVIGSL VGLCTALIMH SPETPVRLGL
241: YGFNSVLCGI AMGGIFFYLN IRTFLYALGC MVLGAIATGA FSVLLSPIGM PALTWPFIVV
301: TWLFLFAGSM FRNIAQVPTE KAGTPEDNLR SLAIGSR