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1.A.28.1.6
Urea transporter 2, UT2, HUT2 or UTB (Solute carrier family 14 member 2) (Urea transporter, kidney).  Knocking out both UT1 and UT2 increases urine output 3.5-fold and lowers urine osmolarity (Jiang et al. 2016). The double knockout also lowered blood pressure and promoted maturation of the male reproductive system. Thus, functional deficiency of all UTs causes a urea-selective urine-concentrating defect with few physiological abnormalities in extrarenal organs (Jiang et al. 2016). A potent inhibitor of both UT1 and UT2 is the thienopyridine, CB-20 (5-ethyl-2-methyl-3-amino-6-methylthieno[2,3-b]pyridine-2,5-dicarboxylate) (Li et al. 2019). UTB  is downregulated in polycythemia vera hematopoietic stem and progenitor cell subpopulations (Tan and Meier-Abt 2021).  Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation (Li et al. 2022).

Accession Number:Q15849
Protein Name:Urea transporter 2
Length:920
Molecular Weight:101209.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:20
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate urea

Cross database links:

Entrez Gene ID: 8170   
Pfam: PF03253   
KEGG: hsa:8170   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0015204 F:urea transmembrane transporter activity
GO:0009414 P:response to water deprivation

References (6)

[1] “Molecular characterization of a new urea transporter in the human kidney.”  Olives B.et.al.   8647271
[2] “Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene.”  Bagnasco S.M.et.al.   11502588
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “DNA sequence and analysis of human chromosome 18.”  Nusbaum C.et.al.   16177791
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.”  Mistry A.C.et.al.   17702749

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK DLRSSNEDSH 
61:	IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG DMKEYRIWLK DKHLALQFID 
121:	WVLRGTAQVM FINNPLSGLI IFIGLLIQNP WWTITGGLGT VVSTLTALAL GQDRSAIASG 
181:	LHGYNGMLVG LLMAVFSEKL DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF 
241:	NIAVTLYLAA TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW 
301:	TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC VLSCIAIGGM 
361:	FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW AFCLATIIFL LLTTNNPAIF 
421:	RLPLSKVTYP EANRIYYLTV KSGEEEKAPS GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH 
481:	IEWSSIRRRS KVFGKGEHQE RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS 
541:	WIRSSMAASG KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG 
601:	ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL VGLLMAVFSD 
661:	KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL PFNITVTLYL AATGHYNLFF 
721:	PTTLLQPASA MPNITWSEVQ VPLLLRAIPV GIGQVYGCDN PWTGGIFLIA LFISSPLICL 
781:	HAAIGSTMGM LAALTIATPF DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF 
841:	AAYLGAALAN MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL 
901:	SQERNRRASI ITKYQAYDVS