TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.31.1.1









Annexin X
Eukaryota
Metazoa, Arthropoda
Annexin X of Drosophila melanogaster
1.A.31.1.2









Annexin VI
Eukaryota
Metazoa, Chordata
Annexin VI of Homo sapiens (673 aas; P08133)
1.A.31.1.3









Annexin A1 (McNeil et al., 2006)

Eukaryota
Metazoa, Chordata
Annexin A1 of Homo sapiens (346 aas; P04083)
1.A.31.1.4









Annexin 2 or Annexin A2 (ANXA2) of 339 aas.  Forms a tetrameric complex with the S100A10 protein and binds the C-terminus of the AHNAK protein via the N-terminus of annexin 2 (De Seranno et al., 2006). Direct translocation of Annexin 2 to the cell surface occurs by pore-formation.  External annexin A2 acts as a plasminogen receptor, able to stimulate fibrinolysis and cell migration (Pompa et al. 2017). Ahnak (of 5890 aas; Q09666) regulates calcium homeostasis in several organs, plays a pivotal role in kidney and ureter development, and maintains the function of the urinary system (Lee et al. 2023). This huge protein consists of > 50 repeat sequences.

Eukaryota
Metazoa, Chordata
Annexin 2 of Homo sapiens
1.A.31.1.5









Non-selective cation channel-forming annexin 1 of 313 aas, Ann1 (Kodavali et al. 2013).

Eukaryota
Viridiplantae, Streptophyta
Ann1 of Medicago truncatula
1.A.31.1.6









Annexxin of 369 aas.  Schistosomiasis, a major parasitic disease of humans, is second only to malaria in its global impact. The disease is caused by digenean trematodes that infest the vasculature of their human hosts. These flukes are limited externally by a body wall composed of a syncytial epithelium, the apical surface membrane, a parasitism-adapted dual membrane complex. Annexins are important for the stability of this apical membrane system. Leow et al. 2013 presented the first structural and immunobiochemical characterization of an annexin from Schistosoma mansoni. The crystal structures of annexin B22 (4MDV and 4MDU) in the apo and Ca2+ bound forms confirmed the presence of the previously predicted α-helical segment in the II/III linker and revealed a covalently linked head-to-head dimer. The dimeric arrangement revealed a non-canonical membrane binding site and a probable binding groove opposite the binding site. Annexin B22 expression correlated with life stages of the parasite that possess the syncytial tegument layer, and ultrastructural localization by immuno-electron microscopy confirmed the occurrence of annexins in the tegument of S. mansoni.

Eukaryota
Metazoa, Platyhelminthes
Annexin B22 of Schistosoma mansoni
1.A.31.1.7









Annexin A5 of 320 aas. Annexin A5 (ANXA5), a Ca2+ and phospholipid binding protein, interacts with the N-terminal leucine-rich repeats of polycystin-1 (TC# 1.A.5.1.2). This interaction is direct and specific, and involves a conserved sequence of the ANXA5 N-terminal domain (Markoff et al. 2007).

Eukaryota
Metazoa, Chordata
Annexin A5 of Homo sapiens
1.A.31.1.8









Annexin D1 (Anx23; Ann1; AnnAT1; AtoxY; Oxy5) of 317 aas. It has a peroxidase activity and may act to counteract oxidative stress (Gorecka et al. 2005). May also mediate regulated, targeted secretion of Golgi-derived vesicles during seedling development (Clark et al. 2005). Can transport Ca2+ (Demidchik et al. 2018).

Eukaryota
Viridiplantae, Streptophyta
Annexin 1D of Arabidopsis thaliana (Mouse-ear cress)
1.A.31.1.9









Annexin XII, Annexin 12, Annexin-12, AnnexinB12 of 316 aas. It is a calcium- and phospholipid-binding protein, phosphorylated by PKC. The x-ray structure of the heximer has been solved (Luecke et al. 1995). A reversible transition occurs between the surface trimer and membrane-inserted monomer (Ladokhin and Haigler 2005).

Eukaryota
Metazoa, Cnidaria
Annexin-12 of Hydra vulgaris