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| Accession Number: | P08133 |
| Protein Name: | Annexin A6 aka Annexin VI aka Lipocortin VI aka P68 aka P70 aka Protein III aka Chromobindin 20 aka 67 kDa calelectrin aka Calphobindin-II aka CPB-II |
| Length: | 673 |
| Molecular Weight: | 75873.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 |
| Substrate | ion |
Cross database links:
| RefSeq: | NP_001146.2 NP_004024.2 |
|---|---|
| Entrez Gene ID: | 309 |
| Pfam: | PF00191 |
| OMIM: |
114070 gene |
| KEGG: | hsa:309 |
Gene Ontology
GO:0042470
C:melanosome
GO:0005509
F:calcium ion binding
GO:0005544
F:calcium-dependent phospholipid binding
GO:0005515
F:protein binding
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References (12)[1] “Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.” Crompton M.R.et.al. 3258820 [2] “Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.” Suedhof T.C.et.al. 2963335 [3] “Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor.” Iwasaki A.et.al. 2528541 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Structure and properties of calphobindin II, an anticoagulant protein from human placenta.” Yoshizaki H.et.al. 2139657 [7] “Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.” Aboulaich N.et.al. 15242332 [8] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.” Chi A.et.al. 17081065 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR SNRQRQEVCQ 61: SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE IKDAISGIGT DEKCLIEILA 121: SRTNEQMHQL VAAYKDAYER DLEADIIGDT SGHFQKMLVV LLQGTREEDD VVSEDLVQQD 181: VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK 241: LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 301: LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR VELKGTVRPA 361: NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ IRQTFKSHFG RDLMTDLKSE 421: ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKALIE ILATRTNAEI RAINEAYKED 481: YHKSLEDALS SDTSGHFRRI LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK 541: TSLETRFMTI LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK 601: PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD 661: FLKALLALCG GED