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|---|---|
| Accession Number: | P04083 |
| Protein Name: | Annexin A1 |
| Length: | 346 |
| Molecular Weight: | 38714.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Nucleus1 |
| Substrate | ion |
Cross database links:
| RefSeq: | NP_000691.1 |
|---|---|
| Entrez Gene ID: | 301 |
| Pfam: | PF00191 |
| OMIM: |
151690 gene |
| KEGG: | hsa:301 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0005929
C:cilium
GO:0001533
C:cornified envelope
GO:0005737
C:cytoplasm
GO:0005576
C:extracellular region
GO:0005634
C:nucleus
GO:0005509
F:calcium ion binding
GO:0005544
F:calcium-dependent phospholipid binding
GO:0019834
F:phospholipase A2 inhibitor activity
GO:0030674
F:protein binding, bridging
GO:0005102
F:receptor binding
GO:0005198
F:structural molecule activity
GO:0006916
P:anti-apoptosis
GO:0007166
P:cell surface receptor linked signaling pathway
GO:0006928
P:cellular component movement
GO:0006954
P:inflammatory response
GO:0030216
P:keratinocyte differentiation
GO:0006629
P:lipid metabolic process
GO:0018149
P:peptide cross-linking
GO:0031340
P:positive regulation of vesicle fusion
GO:0007165
P:signal transduction
| |
References (15)[1] “Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.” Wallner B.P.et.al. 2936963 [2] “Correlation of gene and protein structure of rat and human lipocortin I.” Kovacic R.T.et.al. 1832554 [3] “Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.” Arcone R.et.al. 8425544 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.” Varticovski L.et.al. 2457390 [6] “Characterization by tandem mass spectrometry of structural modifications in proteins.” Biemann K.et.al. 3303336 [7] “A dimeric form of lipocortin-1 in human placenta.” Pepinsky R.B.et.al. 2532504 [8] “Phosphorylation of annexin I by TRPM7 channel-kinase.” Dorovkov M.V.et.al. 15485879 [9] “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.” Rush J.et.al. 15592455 [10] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [11] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.” Rikova K.et.al. 18083107 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV 61: DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL TGHLEEVVLA LLKTPAQFDA 121: DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL 181: LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY 241: TKYSKHDMNK VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM 301: VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN