1.A.31.1.4
Annexin 2 or Annexin A2 (ANXA2) of 339 aas.  Forms a tetrameric complex with the S100A10 protein and binds the C-terminus of the AHNAK protein via the N-terminus of annexin 2 (De Seranno et al., 2006). Direct translocation of Annexin 2 to the cell surface occurs by pore-formation.  External annexin A2 acts as a plasminogen receptor, able to stimulate fibrinolysis and cell migration (Pompa et al. 2017). Ahnak (of 5890 aas; Q09666) regulates calcium homeostasis in several organs, plays a pivotal role in kidney and ureter development, and maintains the function of the urinary system (Lee et al. 2023). This huge protein consists of > 50 repeat sequences.