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|---|---|
| Accession Number: | P0A6Y8 |
| Protein Name: | Chaperone DnaK aka GRPF aka GROP aka SEG aka B0014 |
| Length: | 638 |
| Molecular Weight: | 69115.00 |
| Species: | Escherichia coli [83333] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 / Peripheral membrane protein2 |
| Substrate | ion |
Cross database links:
| DIP: | DIP-35751N |
|---|---|
| RefSeq: | AP_000678.1 NP_414555.1 |
| Entrez Gene ID: | 944750 |
| Pfam: | PF00012 |
| BioCyc: | EcoCyc:EG10241-MONOMER ECOL168927:B0014-MONOMER |
| KEGG: | ecj:JW0013 eco:b0014 |
Gene Ontology
GO:0005737
C:cytoplasm
GO:0005886
C:plasma membrane
GO:0005524
F:ATP binding
GO:0051082
F:unfolded protein binding
GO:0008270
F:zinc ion binding
GO:0006260
P:DNA replication
GO:0006457
P:protein folding
GO:0009408
P:response to heat
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References (18)[1] “Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous.” Bardwell J.C.A.et.al. 6322174 [2] “Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.” Yura T.et.al. 1630901 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Precursor of mitochondrial aspartate aminotransferase synthesized in Escherichia coli is complexed with heat-shock protein DnaK.” Schmid D.et.al. 1396676 [6] “Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.” Link A.J.et.al. 9298646 [7] “Nucleotide sequence of the Escherichia coli dnaJ gene and purification of the gene product.” Ohki M.et.al. 3003084 [8] “The nucleotide sequence of the Escherichia coli K12 dnaJ+ gene. A gene that encodes a heat shock protein.” Bardwell J.C.A.et.al. 3003085 [9] “DNA sequence analysis of the dnaK gene of Escherichia coli B and of two dnaK genes carrying the temperature-sensitive mutations dnaK7(Ts) and dnaK756(Ts).” Miyazaki T.et.al. 1592823 [10] “Involvement of DnaK protein in mini-F plasmid replication: temperature-sensitive seg mutations are located in the dnaK gene.” Ezaki B.et.al. 2674651 [11] “Identification of phosphoproteins in Escherichia coli.” Freestone P.et.al. 7783627 [12] “DnaK as a thermometer: threonine-199 is site of autophosphorylation and is critical for ATPase activity.” McCarty J.S.et.al. 1835085 [13] “Inhibition of DnaK autophosphorylation by heat shock proteins and polypeptide substrates.” Panagiotidis C.A.et.al. 8206983 [14] “Protein complexes of the Escherichia coli cell envelope.” Stenberg F.et.al. 16079137 | |
| Structure: | |
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MGKIIGIDLG TTNSCVAIMD GTTPRVLENA EGDRTTPSII AYTQDGETLV GQPAKRQAVT 61: NPQNTLFAIK RLIGRRFQDE EVQRDVSIMP FKIIAADNGD AWVEVKGQKM APPQISAEVL 121: KKMKKTAEDY LGEPVTEAVI TVPAYFNDAQ RQATKDAGRI AGLEVKRIIN EPTAAALAYG 181: LDKGTGNRTI AVYDLGGGTF DISIIEIDEV DGEKTFEVLA TNGDTHLGGE DFDSRLINYL 241: VEEFKKDQGI DLRNDPLAMQ RLKEAAEKAK IELSSAQQTD VNLPYITADA TGPKHMNIKV 301: TRAKLESLVE DLVNRSIEPL KVALQDAGLS VSDIDDVILV GGQTRMPMVQ KKVAEFFGKE 361: PRKDVNPDEA VAIGAAVQGG VLTGDVKDVL LLDVTPLSLG IETMGGVMTT LIAKNTTIPT 421: KHSQVFSTAE DNQSAVTIHV LQGERKRAAD NKSLGQFNLD GINPAPRGMP QIEVTFDIDA 481: DGILHVSAKD KNSGKEQKIT IKASSGLNED EIQKMVRDAE ANAEADRKFE ELVQTRNQGD 541: HLLHSTRKQV EEAGDKLPAD DKTAIESALT ALETALKGED KAAIEAKMQE LAQVSQKLME 601: IAQQQHAQQQ TAGADASANN AKDDDVVDAE FEEVKDKK