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1.A.35.1.1 Divalent cation (Mg²⁺, Co²⁺ and Ni²⁺) transport system, CorA. Helical tilting and rotation in TM1 generates an iris-like motion that increases the diameter of the permeation pathway, triggering ion conduction, thus defining the gating mechanism (Dalmas et al. 2014).
Accession Number:	P0ABI4
Protein Name:	Magnesium transport protein CorA aka B3816
Length:	316
Molecular Weight:	36590.00
Species:	Escherichia coli [83333]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	magnesium(2+), cobalt(2+), nickel(2+)

Structure:
RefSeq:	AP_003984.1 NP_418260.1
Entrez Gene ID:	948351
Pfam:	PF01544
BioCyc:	EcoCyc:CORA-MONOMER ECOL168927:B3816-MONOMER
KEGG:	ecj:JW3789 eco:b3816
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015087 F:cobalt ion transmembrane transporter activity GO:0015095 F:magnesium ion transmembrane transporter act... GO:0006824 P:cobalt ion transport GO:0015693 P:magnesium ion transport GO:0055085 P:transmembrane transport
References (7) [1] “Sequence and topology of the CorA magnesium transport systems of Salmonella typhimurium and Escherichia coli. Identification of a new class of transport protein.” Smith R.L.et.al. 8314774 [2] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.” Daniels D.L.et.al. 1379743 [3] “Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes.” Plunkett G. IIIet.al. 8346018 [4] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [6] “Mutants in three genes affecting transport of magnesium in Escherichia coli: genetics and physiology.” Park M.H.et.al. 780341 [7] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996
5N77 5N78

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MLSAFQLENN RLTRLEVEES QPLVNAVWID LVEPDDDERL RVQSELGQSL ATRPELEDIE 
61:	ASARFFEDDD GLHIHSFFFF EDAEDHAGNS TVAFTIRDGR LFTLRERELP AFRLYRMRAR 
121:	SQSMVDGNAY ELLLDLFETK IEQLADEIEN IYSDLEQLSR VIMEGHQGDE YDEALSTLAE 
181:	LEDIGWKVRL CLMDTQRALN FLVRKARLPG GQLEQAREIL RDIESLLPHN ESLFQKVNFL 
241:	MQAAMGFINI EQNRIIKIFS VVSVVFLPPT LVASSYGMNF EFMPELKWSF GYPGAIIFMI 
301:	LAGLAPYLYF KRKNWL

1.A.35.1.1
Divalent cation (Mg²⁺, Co²⁺ and Ni²⁺) transport system, CorA. Helical tilting and rotation in TM1 generates an iris-like motion that increases the diameter of the permeation pathway, triggering ion conduction, thus defining the gating mechanism (Dalmas et al. 2014).

Cross database links:

Gene Ontology

References (7)

External Searches:

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1.A.35.1.1Divalent cation (Mg2+, Co2+ and Ni2+) transport system, CorA. Helical tilting and rotation in TM1 generates an iris-like motion that increases the diameter of the permeation pathway, triggering ion conduction, thus defining the gating mechanism (Dalmas et al. 2014).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

1.A.35.1.1
Divalent cation (Mg²⁺, Co²⁺ and Ni²⁺) transport system, CorA. Helical tilting and rotation in TM1 generates an iris-like motion that increases the diameter of the permeation pathway, triggering ion conduction, thus defining the gating mechanism (Dalmas et al. 2014).