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1.A.35.2.2 Inner mitochondrial membrane manganese channel protein Mn^R2p or MRS2-11. The regulatory domain of Mrs2 from the yeast inner mitochondrial membrane is similar to the E. coli regulatory domain of CorA with Met309 serving the same function as Met291 in CorA (Khan et al. 2013).
Accession Number:	P35724
Protein Name:	MNR2 aka YKL064W
Length:	969
Molecular Weight:	109737.00
Species:	Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	magnesium(2+)

DIP:	DIP-8080N
RefSeq:	NP_012859.1
Entrez Gene ID:	853801
Pfam:	PF01544
KEGG:	sce:YKL064W
Gene Ontology GO:0000329 C:fungal-type vacuole membrane GO:0016021 C:integral to membrane GO:0046873 F:metal ion transmembrane transporter activity GO:0005515 F:protein binding GO:0010961 P:cellular magnesium ion homeostasis GO:0030001 P:metal ion transport GO:0055085 P:transmembrane transport
References (8) [1] “Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins.” Rasmussen S.W.et.al. 8091862 [2] “Complete DNA sequence of yeast chromosome XI.” Dujon B.et.al. 8196765 [3] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.” Kim H.et.al. 16847258 [5] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.” Li X.et.al. 17330950 [6] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.” Chi A.et.al. 17287358 [7] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.” Smolka M.B.et.al. 17563356 [8] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.” Albuquerque C.P.et.al. 18407956

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSTDNSQKDE GVPLLSPYSS SPQLRKKKRN QKRRKDKFVG HLKSDSRRPT QLLHDNLQHN 
61:	HGQITDFDQI DSWGMLHESD STSNDIIKSE DPSLKGAFID HRPSMSQPRE GPQSVSSTVQ 
121:	PQPIMKFSTP SYKKPAGLRP SDQNRSLVSD LSPSELESWL KRRKSVHKSF VDENSPTDRR 
181:	QSNANNDVVI DVDALMNHVN NNASTGVNDN SKRRKKKRGS DDSSNKNSKS TSSDSNDEED 
241:	EYNSRPSSSL SSNNSSLDDV CLVLDDEGSE VPKAWPDCTV LEEFSKEETE RLRSQAIQDA 
301:	EAFHFQYDED EEDGTSNEDG ILFSKPIVTN IDVPELGNRR VNETENLKNG RLRPKRIAPW 
361:	HLIQRPMVLG SNSTKDSKSR IQSGLQDNLL VGRNIQYPPH IISNNPEHFR FTYFRVDLDS 
421:	TVHSPTISGL LQPGQKFQDL FVASIYSQDN SAGHIKTHPN SPTPGIKAET VSQLQGLTAK 
481:	NPSTLSSMSV ANIEDVPPFW LDVSNPTEEE MKILSKAFGI HPLTTEDIFL GEVREKVELF 
541:	RDYYLICFRS FDIVAEKHVR RRRKEKQESA TLDHESISRR KSQAYGATMS NESNANNNNS 
601:	TSNASRSKWL PSILRARRRS SANRTTNTSS SSYKRRVKSE KKKMEENEKF KRKSGDRHKP 
661:	REGELEPLNV YIIVFRTGVL TFHFAPTPHP INVRRRARLL KDYLNVTSDW IAYALIDDIT 
721:	DAFAPMIELI EDEVYEIEDA ILKMHQSDDS SDSDSSDSDS DSGASDEDAF PFDVYSKKTS 
781:	YSSAKSSVSS RSMSTSEASF NANLIGWKRK GDMLRRIGEC RKRVMSILRL LGSKADVIKG 
841:	FAKRYNEQWE ASPQSEIAMY LGDIQDHIVT MVSSLNHYEK LLSRSHSNYL AQINIDMTKV 
901:	NNDMNDVLGK ITILGTIVLP MNVITGLWGM NVIVPGQYRD SLTWFIGIVL FMCMLACSAY 
961:	MYTKRRFGF

1.A.35.2.2
Inner mitochondrial membrane manganese channel protein Mn^R2p or MRS2-11. The regulatory domain of Mrs2 from the yeast inner mitochondrial membrane is similar to the E. coli regulatory domain of CorA with Met309 serving the same function as Met291 in CorA (Khan et al. 2013).

Cross database links:

Gene Ontology

References (8)

External Searches:

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1.A.35.2.2Inner mitochondrial membrane manganese channel protein MnR2p or MRS2-11. The regulatory domain of Mrs2 from the yeast inner mitochondrial membrane is similar to the E. coli regulatory domain of CorA with Met309 serving the same function as Met291 in CorA (Khan et al. 2013).

Cross database links:

Gene Ontology

References (8)

External Searches:

Analyze:

1.A.35.2.2
Inner mitochondrial membrane manganese channel protein Mn^R2p or MRS2-11. The regulatory domain of Mrs2 from the yeast inner mitochondrial membrane is similar to the E. coli regulatory domain of CorA with Met309 serving the same function as Met291 in CorA (Khan et al. 2013).