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1.A.35.5.1
Mitochondrial inner membrane Mg2+ channel protein, Mrs2 (Schindl et al., 2007).  Mutational analyses have been carried out, suggesting that internal Mg2+ affects intron splicing (Weghuber et al. 2006). MRS2 is involved in mitochondrial Mg2+ homeostasis (Schäffers et al. 2018). The G-M-N motif determines the ion selectivity, likely together with the negatively charged loop at the entrance of the channel, thereby forming the Mrs2p selectivity filter (Sponder et al. 2013).

Accession Number:Q01926
Protein Name:MRS2 aka YOR334W
Length:470
Molecular Weight:54203.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate magnesium(2+)

Cross database links:

DIP: DIP-5325N
RefSeq: NP_014979.1   
Entrez Gene ID: 854511   
KEGG: sce:YOR334W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015095 F:magnesium ion transmembrane transporter act...
GO:0045016 P:mitochondrial magnesium ion transport

References (8)

[1] “The nuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo.”  Wiesenberger G.et.al.   1551905
[2] “A multitude of suppressors of group II intron-splicing defects in yeast.”  Waldherr M.et.al.   8252639
[3] “Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I.”  Parle-McDermott A.G.et.al.   8896263
[4] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[5] “Insertion of bitopic membrane proteins into the inner membrane of mitochondria involves an export step from the matrix.”  Baumann F.et.al.   11932259
[6] “Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria.”  Kolisek M.et.al.   12628916
[7] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[8] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
Structure:
3RKG     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNRRLLVRSI SCFQPLSRIT FGRPNTPFLR KYADTSTAAN TNSTILRKQL LSLKPISASD 
61:	SLFISCTVFN SKGNIISMSE KFPKWSFLTE HSLFPRDLRK IDNSSIDIIP TIMCKPNCIV 
121:	INLLHIKALI ERDKVYVFDT TNPSAAAKLS VLMYDLESKL SSTKNNSQFY EHRALESIFI 
181:	NVMSALETDF KLHSQICIQI LNDLENEVNR LKLRHLLIKS KDLTLFYQKT LLIRDLLDEL 
241:	LENDDDLANM YLTVKKSPKD NFSDLEMLIE TYYTQCDEYV QQSESLIQDI KSTEEIVNII 
301:	LDANRNSLML LELKVTIYTL GFTVASVLPA FYGMNLKNFI EESEWGFTSV AVFSIVSALY 
361:	ITKKNFNSLR SVTKMTMYPN SPANSSVYPK TSASIALTNK LKRRRKWWKS TKQRLGVLLY 
421:	GSSYTNKANL SNNKINKGFS KVKKFNMEND IKNKQNRDMI WKWLIEDKKN