Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.35.5.5
Mitochondrial inner membrane magnesium transporter MFM1; LPE10 (MRS2 function modulating factor 1)

Accession Number:Q02783
Protein Name:Mitochondrial inner membrane magnesium transporter MFM1
Length:413
Molecular Weight:47083.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate magnesium(2+)

Cross database links:

DIP: DIP-4653N
Entrez Gene ID: 856045   
KEGG: sce:YPL060W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015095 F:magnesium ion transmembrane transporter activity
GO:0045016 P:mitochondrial magnesium ion transport
GO:0006397 P:mRNA processing
GO:0008380 P:RNA splicing

References (8)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875
[2] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[3] “The mitochondrial inner membrane protein Lpe10p, a homologue of Mrs2p, is essential for magnesium homeostasis and group II intron splicing in yeast.”  Gregan J.et.al.   11254124
[4] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[6] “Mrs2p forms a high conductance Mg2+ selective channel in mitochondria.”  Schindl R.et.al.   17827224
[7] “Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.”  Kung L.A.et.al.   19756047
[8] “Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.”  Sponder G.et.al.   20653776

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MRAFPRVLPF RHQRSYNNIL LRTVRLFGSS LSSFDFSRQM PKVDPDNTAA MLLQKNLIQR 
61:	NNMLYGYGSG TIRCTLLDST GRAKSPLVEI KREDLVSKHG LLPRDLRKIE KSRKNDLVPS 
121:	LLVRENSILI SLLTVKALIK PDMVIIFDSA GSGITLNSEA HKDFINDMKL RLKNQETSEL 
181:	NSDPLPYEFR ALETIFISAL SNLTSEMKVL LTICKGVLQD LEFSITRDKL RFLLGQNKKL 
241:	SSFNKKAVLV KDMLDDLLEQ DDMLCDMYLT DKKAGKIRVQ DDHTEIEMLL ETYHNYVDEI 
301:	VQKSESAISD VKTTEEIINI ILDSNRNELM LLGIRYAIGM LSLGGALFLG SIYGMNLESF 
361:	IEESNYAYLT VTILGLISTV WLYAKGIRHL HKLQRMTLLS KIKTDSVHEL LKK