1.A.37.3.2
MS4A2 of 244 aas and 4 TMSs. High affinity receptor that binds to the Fc
region of immunoglobulins epsilon. Aggregation of Fc epsilon receptor (FCERI) by multivalent
antigens is required for the full mast cell response, including the
release of preformed mediators (such as histamine) by degranulation and
de novo production of lipid mediators and cytokines (Penhallow et al. 1995). Also mediates the
secretion of important lymphokines. Binding of allergen to
receptor-bound IgE leads to cell activation and the release of mediators
responsible for the manifestations of allergy.
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| Accession Number: | Q01362 |
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| Protein Name: | High affinity immunoglobulin epsilon receptor subunit beta |
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| Length: | 244 |
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| Molecular Weight: | 26534.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
signalling molecule |
|---|
1: MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF
61: LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY PFWGAIFFSI SGMLSIISER
121: RNATYLVRGS LGANTASSIA GGTGITILII NLKKSLAYIH IHSCQKFFET KCFMASFSTE
181: IVVMMLFLTI LGLGSAVSLT ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP
241: PIDL