TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.38.1.1









The Golgi pH regulator, GPHR, of 455 aas and 9 TMSs in a 5 + 4 TMS arrangement.

Eukaryota
Metazoa
GPHR of Cricetulus griseus (B2ZXD5)
1.A.38.1.2









Uncharacterized protein of 367 aas and 8 TMSs.

Eukaryota
Entamoebidae
UP of Entamoeba histolytica
1.A.38.1.3









The GPCR-type G protein, COLD1, of 455 aas and 9 TMSs in a 5 + 4 TMS arrangement. In cold tolerant cultivars (AC Q7X7S8) Met-187 is replaced by Lys-187. This polymorphism is associated with divergence in chilling tolerance of rice cultivars. COLD1 confers adaptation of japonica rice to chilling and originated from the Chinese wild populations of Oryza rufipogon (Ma et al. 2015).
Overexpression of COLD1(jap) significantly enhances chilling tolerance, whereas rice lines with a deficiency or downregulation of COLD1(jap) are sensitive to cold. COLD1 encodes a regulator of G-protein signaling that localizes to the plasma membrane and endoplasmic reticulum (ER). It interacts with the G-protein α subunit to activate the Ca2+ channel for sensing low temperature and to accelerate G-protein GTPase activity (Ma et al. 2015).

Eukaryota
Viridiplantae
COLD1 of Oryza sativa subsp. indica (Rice)
1.A.38.2.1









10 TMS homologue (826 aas)

Eukaryota
Kinetoplastida
10 TMS homologue of Leishmania mexicana (E9AL43)
1.A.38.3.1









4-5 TMS homologue (398 aas)

Eukaryota
Apicomplexa
4-5 TMS homologue of Plasmodium yoelii (Q7RQA4)