1.A.4.5.11
Transient receptor potential cation channel subfamily M member 8, TrpM8, the primary cold and menthol receptor in humans. The structure has been solved for the collared flycatcher at 4.1 Å resolution (6BPQ_A - D (Yin et al. 2017).
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| Accession Number: | 6BPQ_A |
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| Protein Name: | A Chain A, Structure of the cold- and menthol-sensing ion channel TRPM8 |
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| Length: | 951 |
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| Molecular Weight: | |
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| Species: | Ficedula albicollis [59894] |
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| Number of TMSs: | 6 |
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| Substrate |
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1: XXXXXXXXXX XXXXXXXXXX CDTDSETLYD LMTQHWHLKT PNLVISVTGG AKNFALKPRM
61: RKIFSRLIYI AQSKGAWIFT GGTHYGLMKY IGEVVRDNTI SRSSEENVVA IGIAXXXXXL
121: KRDPLYCLDN NHTHLLLVDN GTHGHPTIEA KVRTQLEKYI SERVIPESNY GGKIPIVCFA
181: QGGGKETLKS INVAIKSKIP CVVVEGSGRI ADVIASLVEA EGTLASSCVK ESLLRFLPRT
241: ISRLSEEETE SWIKWIKEVL ESPHLLTVIK IEEAGDEIVS NAISFALYKA FSTNEHDRDN
301: WNGQLKLLLE WNQLDLASDE IFTNDRNWES ADLQDVMFTA LVKDRPKFVR LFLENGLNLR
361: KFLTTEVLRE LYTNNFSSLV FKNLQIAKNS YNDALLTFVW KMVEDFRRGA KRDDKNSKDE
421: MEIELSEECP ITRHPLQALF IWSVLQNKKE LSKVIWEQTR GCTLAALGAS KLLKSMAKVK
481: NDINAAGESE ELANEYETRA VELFTECYSN DEDLAEQLLT YSCEAWGGSN CLELAVEARD
541: QQFIAQPGVQ NFLSKQWYGE ISRDTKNWKI ILCLFFFPLI GCGFISFRKK PVEKTKKLFL
601: YYVSFFTSPF VVFSWNVIFY IAFLLLFAYV LLMDFQKEPT ALEIILYVLV FILLCDEVRQ
661: WYMNGSKYFS DLWNVMDTLA IFYFIAGIVF RLHSDESSWY SGRVIFCLDY IVFTLRLIHI
721: FTVSRNLGPK IIMLQRMMID VFFFLFLFAV WMVAFGVARQ GILRKNEHRW EWIFRSVIYE
781: PYLAMFGQYP DDIDGTTYNF DHCTFSGNES KPLCVELDAN NQPRFPEWIT IPLVCIYMLS
841: TNILLVNLLV AMFGYTVGSV QENNDQVWKF QRFFLVQEYC SRLTXXXXXX XXXXXXXXXX
901: XXRNEDNEIL AWEAVMKENY LVKINTXXXX XXXXXXXXXX XXXXXXXXXX