1.A.43.1.1
The camphor resistance protein, CrcB or FluC (Hu et al. 1996; Sand et al. 2003).  Exports fluoride selectively over chloride by an anion open channel mechanism (Stockbridge et al. 2013).  The active transporter is a dimer of 4 TMS subunits arranged in an antiparallel transmembrane orientation (Stockbridge et al. 2014).  In bacteria lacking Fluc, F^- accumulates when the external medium is acidified as a predicted function of the transmembrane pH gradient. This weak acid accumulation effect, which results from the high pKa (3.4) and membrane permeability of HF, is abolished by Fluc channels (Ji et al. 2014).  A proper tubulin network is required for functional Cx43 GJ channels, and mefloquineis a gap junction inhibitor (Sand et al. 2003).  Exports fluoride selectively over chloride by an anion open channel mechanism (Stockbridge et al. 2013).  The active transporter is a dimer of 4 TMS subunits arranged in an antiparallel transmembrane orientation (Stockbridge et al. 2014).  In bacteria lacking Fluc, F^- accumulates when the external medium is acidified as a predicted function of the transmembrane pH gradient. This weak acid accumulation effect, which results from the high pKa (3.4) and membrane permeability of HF, is abolished by Fluc channels (Ji et al. 2014).  A proper tubulin network is required for functional Cx43 GJ channels, and mefloquineis a gap junction inhibitor (Picoli et al. 2019). .