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1.A.46.1.4 Bestrophin 3 vitelliform macular dystrophy 2-like protein 3 (possesses a C-terminal motif blocking its own channel activity (Qu et al., 2006). Ca²⁺activates anion flux with SCN^->I^->Cl^-.
Accession Number:	Q6H1V1
Protein Name:	Bestrophin-3 aka Best3
Length:	669
Molecular Weight:	76431.00
Species:	Mus musculus (Mouse) [10090]
Number of TMSs:	5
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	chloride, iodide, isothiocyanato group

RefSeq:	NP_001007584.1
Entrez Gene ID:	382427
Pfam:	PF01062
KEGG:	mmu:382427
Gene Ontology GO:0034707 C:chloride channel complex GO:0005886 C:plasma membrane GO:0005254 F:chloride channel activity GO:0015698 P:inorganic anion transport GO:0043271 P:negative regulation of ion transport
References (1) [1] “Cloning and characterization of the murine Vmd2 RFP-TM gene family.” Kraemer F.et.al. 15218265

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MTVTYSSKVA NATFFGFHRL LLKWRGSIYK LLYREFIVFA VLYTAISLVY RLLLTGAQKR 
61:	YFEKLSIYCD RYAEQIPVTF VLGFYVTLVV NRWWNQFVNL PWPDRLMLLI SSSVHGSDQH 
121:	GRLLRRTLMR YVNLTSLLIF RSVSTAVYKR FPTMDHVVEA GFMTADERKL FDHLKSPHLK 
181:	YWVPFIWFGN LATKARNEGR IRDSVDLQSL MTEMNRYRSW CSLLFGYDWV GIPLVYTQVV 
241:	TLAVYTFFFA CLIGRQFLDP TKGYVGHDLD LYVPIFTLLQ FFFYAGWLKV AEQLINPFGE 
301:	DDDDFETNWC IDRNLQVSLL AVDEMHMSLP KMKKDIYWDD SAARPPYTLA AADYCIPSFL 
361:	GSTIQMGLSG SNFPAEDWLW NYEKHGNRHS VMRRVKRFLS THEHPGSPRR RRSFGRQASD 
421:	SSMFLPPSPA RDLLDVPSRN PHRGSPTRKQ SRSQEGSPKL HSSMGELSTI RETSRTSTLQ 
481:	SLSPQSSVRS SPTKMPQVPE VLITAAEAPA FSADSHQHDS TTSILSLEFT GVQPSGTEQQ 
541:	VEPSGTPPGD PNPQTTSAST ERDLFKFEED LEDDRFPKRW SLPEFLESRH TSLGNLGPDP 
601:	VSPRDALLLP DTETPSETNG IHPGAGSALA PDILYLMESL DKETDILEFN NEHTGESPKG 
661:	TPQRPRTWF

1.A.46.1.4
Bestrophin 3 vitelliform macular dystrophy 2-like protein 3 (possesses a C-terminal motif blocking its own channel activity (Qu et al., 2006). Ca²⁺activates anion flux with SCN^->I^->Cl^-.

Cross database links:

Gene Ontology

References (1)

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1.A.46.1.4Bestrophin 3 vitelliform macular dystrophy 2-like protein 3 (possesses a C-terminal motif blocking its own channel activity (Qu et al., 2006). Ca2+ activates anion flux with SCN->I->Cl-.

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.A.46.1.4
Bestrophin 3 vitelliform macular dystrophy 2-like protein 3 (possesses a C-terminal motif blocking its own channel activity (Qu et al., 2006). Ca²⁺activates anion flux with SCN^->I^->Cl^-.