1.A.46.1.5
Bestrophin1, isoform B. Identified as the Cl- (swell) channel that allows swelling in hypo-osmotic solutions (Stotz and Clapham 2012). Its N-terminal 64 aas are essential for swell activation.
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| Accession Number: | B7Z0U6 |
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| Protein Name: | Bestrophin 1, isoform B |
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| Length: | 769 |
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| Molecular Weight: | 84350.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 5 |
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| Substrate |
chloride |
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| Entrez Gene ID: |
53431
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| Pfam: |
PF01062
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| KEGG: |
dme:Dmel_CG6264
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[1] “The genome sequence of Drosophila melanogaster.” Adams M.D. et.al. 10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.” Misra S. et.al. 12537572
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1: MTITYTGEVA TCRGFGCFLK LLLRWRGSIY KLVWLDLLAF LTIYYAINMV YRFGLNPAQK
61: ETFEAIVQYC DSYRELIPLS FVLGFYVSIV MTRWWNQYTS IPWPDPIAVF VSSNVHGQDE
121: RGRMMRRTIM RYVCLCLTMV LANVSPRVKK RFPGLNNLVE AGLLNDNEKT IIETMNKAFP
181: RPSKHWLPIV WAASIITRAR KEGRIRDDFA VKTIIDELNK FRGQCGLLIS YDTISVPLVY
241: TQVVTLAVYS YFLTCCMGQQ WTDGKVVGNT TYLNKVDLYF PVFTTLQFFF YMGWLKVAES
301: LINPFGEDDD DFEVNWMVDR NLQVSYLIVD EMHHDHPELL KDQYWDEVFP NELPYTIAAE
361: RFRENHPEPS TAKIEVPKNA AMPSTMSSVR IDEMVGNANG DPAAAADAKA PNPVTGQVQV
421: PGADTGVQTV TYDFPKGSPD EEADDASGIH FSAGNGKMRL DSSPSLVSVS GTLSRVNTVA
481: SALKRFLSRD DSRPGSATPS QDQPYKFPAS ASSASLSGAV VGSATSAGKP AGSLRITQQV
541: IEEVDEQATI TSMRANDPRP NVMDIFAQTS SGAGTSGPLQ PPPAHSEPVD IPSRPPSYNR
601: AQSQYEPNLF PPGGVDALLS TSAPAGGSPL LLSNAATAPS SPVGESSKSL YDPQKGASRE
661: TVESMDLRSS TDLLGDAAVQ PEDEGDDFDK LKAEREKEKL MRQQKNLART ISTAPGMEAT
721: AVPMVPMVPV NVAVQQAQLQ PVASSADLLA GGDQFSNSTM KSEDAINGS