1.A.46.1.8
Bestrophin-3, BEST3, Vmd2L3 of 668 aas and 7 TMSs. It forms calcium-sensitive chloride channels permeable to monovalent anions including bicarbonate (Tsunenari et al. 2003). It's expression prevents ER-stress-induced cell death in renal peithelial cells (Lee et al. 2012). It is expressed in glial cells of the brain (Wang et al. 2019), and when mutant may cause mandibular prognathism (Kajii et al. 2019). Vitamin C induces expression (Wang et al. 2019).
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| Accession Number: | Q8N1M1 |
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| Protein Name: | Bestrophin-3 |
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| Length: | 668 |
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| Molecular Weight: | 76107.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MTVTYSSKVA NATFFGFHRL LLKWRGSIYK LLYREFIVFA VLYTAISLVY RLLLTGVQKR
61: YFEKLSIYCD RYAEQIPVTF VLGFYVTLVV NRWWNQFVNL PWPDRLMFLI SSSVHGSDEH
121: GRLLRRTLMR YVNLTSLLIF RSVSTAVYKR FPTMDHVVEA GFMTTDERKL FNHLKSPHLK
181: YWVPFIWFGN LATKARNEGR IRDSVDLQSL MTEMNRYRSW CSLLFGYDWV GIPLVYTQVV
241: TLAVYTFFFA CLIGRQFLDP TKGYAGHDLD LYIPIFTLLQ FFFYAGWLKV AEQLINPFGE
301: DDDDFETNWC IDRNLQVSLL AVDEMHMSLP KMKKDIYWDD SAARPPYTLA AADYCIPSFL
361: GSTVQMGLSG SDFPDEEWLW DYEKHGHRHS MIRRVKRFLS AHEHPSSPRR RSYRRQTSDS
421: SMFLPRDDLS PARDLLDVPS RNPPRASPTW KKSCFPEGSP TLHFSMGELS TIRETSQTST
481: LQSLTPQSSV RTSPIKMPLV PEVLITAAEA PVPTSGGYHH DSATSILSSE FTGVQPSKTE
541: QQQGPMGSIL SPSEKETPPG GPSPQTVSAS AEENIFNCEE DPGDTFLKRW SLPGFLGSSH
601: TSLGNLSPDP MSSQPALLID TETSSEISGI NIVAGSRVSS DMLYLMENLD TKETDIIELN
661: KETEESPK