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1.A.53.1.11
Hepatitis GB virus B (GBV-B) polyprotein of 2864 aas, containing the p13 viroporin.  It is found between residues 614 and 733 in the polyprotein and has 4 predicted TMSs.  It is homologous to but larger than the p7 protein of hepatitis C virus (Ghibaudo et al. 2004).

Accession Number:Q69422
Protein Name:Genome polyprotein
Length:2864
Molecular Weight:312705.00
Species:Hepatitis GB virus B (GBV-B) [39113]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Host endoplasmic reticulum membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Structure:
2LZP   2LZQ   2MKB     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MPVISTQTSP VPAPRTRKNK QTQASYPVSI KTSVERGQRA KRKVQRDARP RNYKIAGIHD 
61:	GLQTLAQAAL PAHGWGRQDP RHKSRNLGIL LDYPLGWIGD VTTHTPLVGP LVAGAVVRPV 
121:	CQIVRLLEDG VNWATGWFGV HLFVVCLLSL ACPCSGARVT DPDTNTTILT NCCQRNQVIY 
181:	CSPSTCLHEP GCVICADECW VPANPYISHP SNWTGTDSFL ADHIDFVMGA LVTCDALDIG 
241:	ELCGACVLVG DWLVRHWLIH IDLNETGTCY LEVPTGIDPG FLGFIGWMAG KVEAVIFLTK 
301:	LASQVPYAIA TMFSSVHYLA VGALIYYASR GKWYQLLLAL MLYIEATSGN PIRVPTGCSI 
361:	AEFCSPLMIP CPCHSYLSEN VSEVICYSPK WTRPVTLEYN NSISWYPYTI PGARGCMVKF 
421:	KNNTWGCCRI RNVPSYCTMG TDAVWNDTRN TYEACGVTPW LTTAWHNGSA LKLAILQYPG 
481:	SKEMFKPHNW MSGHLYFEGS DTPIVYFYDP VNSTLLPPER WARLPGTPPV VRGSWLQVPQ 
541:	GFYSDVKDLA TGLITKDKAW KNYQVLYSAT GALSLTGVTT KAVVLILLGL CGSKYLILAY 
601:	LCYLSLCFGR ASGYPLRPVL PSQSYLQAGW DVLSKAQVAP FALIFFICCY LRCRLRYAAL 
661:	LGFVPMAAGL PLTFFVAAAA AQPDYDWWVR LLVAGLVLWA GRDRGPRIAL LVGPWPLVAL 
721:	LTLLHLATPA SAFDTEIIGG LTIPPVVALV VMSRFGFFAH LLPRCALVNS YLWQRWENWF 
781:	WNVTLRPERF LLVLVCFPGA TYDTLVTFCV CHVALLCLTS SAASFFGTDS RVRAHRMLVR 
841:	LGKCHAWYSH YVLKFFLLVF GENGVFFYKH LHGDVLPNDF ASKLPLQEPF FPFEGKARVY 
901:	RNEGRRLACG DTVDGLPVVA RLGDLVFAGL AMPPDGWAIT APFTLQCLSE RGTLSAMAVV 
961:	MTGIDPRTWT GTIFRLGSLA TSYMGFVCDN VLYTAHHGSK GRRLAHPTGS IHPITVDAAN 
1021:	DQDIYQPPCG AGSLTRCSCG ETKGYLVTRL GSLVEVNKSD DPYWCVCGAL PMAVAKGSSG 
1081:	APILCSSGHV IGMFTAARNS GGSVSQIRVR PLVCAGYHPQ YTAHATLDTK PTVPNEYSVQ 
1141:	ILIAPTGSGK STKLPLSYMQ EKYEVLVLNP SVATTASMPK YMHATYGVNP NCYFNGKCTN 
1201:	TGASLTYSTY GMYLTGACSR NYDVIICDEC HATDATTVLG IGKVLTEAPS KNVRLVVLAT 
1261:	ATPPGVIPTP HANITEIQLT DEGTIPFHGK KIKEENLKKG RHLIFEATKK HCDELANELA 
1321:	RKGITAVSYY RGCDISKIPE GDCVVVATDA LCTGYTGDFD SVYDCSLMVE GTCHVDLDPT 
1381:	FTMGVRVCGV SAIVKGQRRG RTGRGRAGIY YYVDGSCTPS GMVPECNIVE AFDAAKAWYG 
1441:	LSSTEAQTIL DTYRTQPGLP AIGANLDEWA DLFSMVNPEP SFVNTAKRTA DNYVLLTAAQ 
1501:	LQLCHQYGYA APNDAPRWQG ARLGKKPCGV LWRLDGADAC PGPEPSEVTR YQMCFTEVNT 
1561:	SGTAALAVGV GVAMAYLAID TFGATCVRRC WSITSVPTGA TVAPVVDEEE IVEECASFIP 
1621:	LEAMVAAIDK LKSTITTTSP FTLETALEKL NTFLGPHAAT ILAIIEYCCG LVTLPDNPFA 
1681:	SCVFAFIAGI TTPLPHKIKM FLSLFGGAIA SKLTDARGAL AFMMAGAAGT ALGTWTSVGF 
1741:	VFDMLGGYAA ASSTACLTFK CLMGEWPTMD QLAGLVYSAF NPAAGVVGVL SACAMFALTT 
1801:	AGPDHWPNRL LTMLARSNTV CNEYFIATRD IRRKILGILE ASTPWSVISA CIRWLHTPTE 
1861:	DDCGLIAWGL EIWQYVCNFF VICFNVLKAG VQSMVNIPGC PFYSCQKGYK GPWIGSGMLQ 
1921:	ARCPCGAELI FSVENGFAKL YKGPRTCSNY WRGAVPVNAR LCGSARPDPT DWTSLVVNYG 
1981:	VRDYCKYEKL GDHIFVTAVS SPNVCFTQVP PTLRAAVAVD GVQVQCYLGE PKTPWTTSAC 
2041:	CYGPDGKGKT VKLPFRVDGH TPGVRMQLNL RDALETNDCN SINNTPSDEA AVSALVFKQE 
2101:	LRRTNQLLEA ISAGVDTTKL PAPSIEEVVV RKRQFRARTG SLTLPPPPRS VPGVSCPESL 
2161:	QRSDPLEGPS NLPSSPPVLQ LAMPMPLLGA GECNPFTAIG CAMTETGGGP DDLPSYPPKK 
2221:	EVSEWSDGSW STTTTASSYV TGPPYPKIRG KDSTQSAPAK RPTKKKLGKS EFSCSMSYTW 
2281:	TDVISFKTAS KVLSATRAIT SGFLKQRSLV YVTEPRDAEL RKQKVTINRQ PLFPPSYHKQ 
2341:	VRLAKEKASK VVGVMWDYDE VAAHTPSKSA KSHITGLRGT DVRSGAARKA VLDLQKCVEA 
2401:	GEIPSHYRQT VIVPKEEVFV KTPQKPTKKP PRLISYPHLE MRCVEKMYYG QVAPDVVKAV 
2461:	MGDAYGFVDP RTRVKRLLSM WSPDAVGATC DTVCFDSTIT PEDIMVETDI YSAAKLSDQH 
2521:	RAGIHTIARQ LYAGGPMIAY DGREIGYRRC RSSGVYTTSS SNSLTCWLKV NAAAEQAGMK 
2581:	NPRFLICGDD CTVIWKSAGA DADKQAMRVF ASWMKVMGAP QDCVPQPKYS LEELTSCSSN 
2641:	VTSGITKSGK PYYFLTRDPR IPLGRCSAEG LGYNPSAAWI GYLIHHYPCL WVSRVLAVHF 
2701:	MEQMLFEDKL PETVTFDWYG KNYTVPVEDL PSIIAGVHGI EAFSVVRYTN AEILRVSQSL 
2761:	TDMTMPPLRA WRKKARAVLA SAKRRGGAHA KLARFLLWHA TSRPLPDLDK TSVARYTTFN 
2821:	YCDVYSPEGD VFVTPQRRLQ KFLVKYLAVI VFALGLIAVG LAIS