1.A.53.1.11
Hepatitis GB virus B (GBV-B) polyprotein of 2864 aas, containing the p13 viroporin. It is found between residues 614 and 733 in the polyprotein and has 4 predicted TMSs. It is homologous to but larger than the p7 protein of hepatitis C virus (Ghibaudo et al. 2004).
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| Accession Number: | Q69422 |
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| Protein Name: | Genome polyprotein |
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| Length: | 2864 |
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| Molecular Weight: | 312705.00 |
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| Species: | Hepatitis GB virus B (GBV-B) [39113] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Host endoplasmic reticulum membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MPVISTQTSP VPAPRTRKNK QTQASYPVSI KTSVERGQRA KRKVQRDARP RNYKIAGIHD
61: GLQTLAQAAL PAHGWGRQDP RHKSRNLGIL LDYPLGWIGD VTTHTPLVGP LVAGAVVRPV
121: CQIVRLLEDG VNWATGWFGV HLFVVCLLSL ACPCSGARVT DPDTNTTILT NCCQRNQVIY
181: CSPSTCLHEP GCVICADECW VPANPYISHP SNWTGTDSFL ADHIDFVMGA LVTCDALDIG
241: ELCGACVLVG DWLVRHWLIH IDLNETGTCY LEVPTGIDPG FLGFIGWMAG KVEAVIFLTK
301: LASQVPYAIA TMFSSVHYLA VGALIYYASR GKWYQLLLAL MLYIEATSGN PIRVPTGCSI
361: AEFCSPLMIP CPCHSYLSEN VSEVICYSPK WTRPVTLEYN NSISWYPYTI PGARGCMVKF
421: KNNTWGCCRI RNVPSYCTMG TDAVWNDTRN TYEACGVTPW LTTAWHNGSA LKLAILQYPG
481: SKEMFKPHNW MSGHLYFEGS DTPIVYFYDP VNSTLLPPER WARLPGTPPV VRGSWLQVPQ
541: GFYSDVKDLA TGLITKDKAW KNYQVLYSAT GALSLTGVTT KAVVLILLGL CGSKYLILAY
601: LCYLSLCFGR ASGYPLRPVL PSQSYLQAGW DVLSKAQVAP FALIFFICCY LRCRLRYAAL
661: LGFVPMAAGL PLTFFVAAAA AQPDYDWWVR LLVAGLVLWA GRDRGPRIAL LVGPWPLVAL
721: LTLLHLATPA SAFDTEIIGG LTIPPVVALV VMSRFGFFAH LLPRCALVNS YLWQRWENWF
781: WNVTLRPERF LLVLVCFPGA TYDTLVTFCV CHVALLCLTS SAASFFGTDS RVRAHRMLVR
841: LGKCHAWYSH YVLKFFLLVF GENGVFFYKH LHGDVLPNDF ASKLPLQEPF FPFEGKARVY
901: RNEGRRLACG DTVDGLPVVA RLGDLVFAGL AMPPDGWAIT APFTLQCLSE RGTLSAMAVV
961: MTGIDPRTWT GTIFRLGSLA TSYMGFVCDN VLYTAHHGSK GRRLAHPTGS IHPITVDAAN
1021: DQDIYQPPCG AGSLTRCSCG ETKGYLVTRL GSLVEVNKSD DPYWCVCGAL PMAVAKGSSG
1081: APILCSSGHV IGMFTAARNS GGSVSQIRVR PLVCAGYHPQ YTAHATLDTK PTVPNEYSVQ
1141: ILIAPTGSGK STKLPLSYMQ EKYEVLVLNP SVATTASMPK YMHATYGVNP NCYFNGKCTN
1201: TGASLTYSTY GMYLTGACSR NYDVIICDEC HATDATTVLG IGKVLTEAPS KNVRLVVLAT
1261: ATPPGVIPTP HANITEIQLT DEGTIPFHGK KIKEENLKKG RHLIFEATKK HCDELANELA
1321: RKGITAVSYY RGCDISKIPE GDCVVVATDA LCTGYTGDFD SVYDCSLMVE GTCHVDLDPT
1381: FTMGVRVCGV SAIVKGQRRG RTGRGRAGIY YYVDGSCTPS GMVPECNIVE AFDAAKAWYG
1441: LSSTEAQTIL DTYRTQPGLP AIGANLDEWA DLFSMVNPEP SFVNTAKRTA DNYVLLTAAQ
1501: LQLCHQYGYA APNDAPRWQG ARLGKKPCGV LWRLDGADAC PGPEPSEVTR YQMCFTEVNT
1561: SGTAALAVGV GVAMAYLAID TFGATCVRRC WSITSVPTGA TVAPVVDEEE IVEECASFIP
1621: LEAMVAAIDK LKSTITTTSP FTLETALEKL NTFLGPHAAT ILAIIEYCCG LVTLPDNPFA
1681: SCVFAFIAGI TTPLPHKIKM FLSLFGGAIA SKLTDARGAL AFMMAGAAGT ALGTWTSVGF
1741: VFDMLGGYAA ASSTACLTFK CLMGEWPTMD QLAGLVYSAF NPAAGVVGVL SACAMFALTT
1801: AGPDHWPNRL LTMLARSNTV CNEYFIATRD IRRKILGILE ASTPWSVISA CIRWLHTPTE
1861: DDCGLIAWGL EIWQYVCNFF VICFNVLKAG VQSMVNIPGC PFYSCQKGYK GPWIGSGMLQ
1921: ARCPCGAELI FSVENGFAKL YKGPRTCSNY WRGAVPVNAR LCGSARPDPT DWTSLVVNYG
1981: VRDYCKYEKL GDHIFVTAVS SPNVCFTQVP PTLRAAVAVD GVQVQCYLGE PKTPWTTSAC
2041: CYGPDGKGKT VKLPFRVDGH TPGVRMQLNL RDALETNDCN SINNTPSDEA AVSALVFKQE
2101: LRRTNQLLEA ISAGVDTTKL PAPSIEEVVV RKRQFRARTG SLTLPPPPRS VPGVSCPESL
2161: QRSDPLEGPS NLPSSPPVLQ LAMPMPLLGA GECNPFTAIG CAMTETGGGP DDLPSYPPKK
2221: EVSEWSDGSW STTTTASSYV TGPPYPKIRG KDSTQSAPAK RPTKKKLGKS EFSCSMSYTW
2281: TDVISFKTAS KVLSATRAIT SGFLKQRSLV YVTEPRDAEL RKQKVTINRQ PLFPPSYHKQ
2341: VRLAKEKASK VVGVMWDYDE VAAHTPSKSA KSHITGLRGT DVRSGAARKA VLDLQKCVEA
2401: GEIPSHYRQT VIVPKEEVFV KTPQKPTKKP PRLISYPHLE MRCVEKMYYG QVAPDVVKAV
2461: MGDAYGFVDP RTRVKRLLSM WSPDAVGATC DTVCFDSTIT PEDIMVETDI YSAAKLSDQH
2521: RAGIHTIARQ LYAGGPMIAY DGREIGYRRC RSSGVYTTSS SNSLTCWLKV NAAAEQAGMK
2581: NPRFLICGDD CTVIWKSAGA DADKQAMRVF ASWMKVMGAP QDCVPQPKYS LEELTSCSSN
2641: VTSGITKSGK PYYFLTRDPR IPLGRCSAEG LGYNPSAAWI GYLIHHYPCL WVSRVLAVHF
2701: MEQMLFEDKL PETVTFDWYG KNYTVPVEDL PSIIAGVHGI EAFSVVRYTN AEILRVSQSL
2761: TDMTMPPLRA WRKKARAVLA SAKRRGGAHA KLARFLLWHA TSRPLPDLDK TSVARYTTFN
2821: YCDVYSPEGD VFVTPQRRLQ KFLVKYLAVI VFALGLIAVG LAIS