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| Accession Number: | O92530 |
| Protein Name: | Genome polyprotein |
| Length: | 3013 |
| Molecular Weight: | 328200.00 |
| Species: | Hepatitis C virus genotype 6d (isolate VN235) (HCV) [356422] |
| Number of TMSs: | 15 |
| Location1 / Topology2 / Orientation3: | Host endoplasmic reticulum membrane1 / Single-pass type I membrane protein2 |
| Substrate | cation |
Cross database links:
| Pfam: | PF07652 PF01543 PF01542 PF01539 PF01560 PF01538 PF01006 PF01001 PF01506 PF08300 PF08301 PF12941 PF02907 PF00998 PF07652 PF01543 PF01542 PF01539 PF01560 PF01538 PF01006 PF01001 PF01506 PF08300 PF08301 PF12941 PF02907 PF00998 |
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Gene Ontology
GO:0044167
C:host cell endoplasmic reticulum membrane
GO:0044186
C:host cell lipid particle
GO:0044191
C:host cell mitochondrial membrane
GO:0042025
C:host cell nucleus
GO:0044220
C:host cell perinuclear region of cytoplasm
GO:0020002
C:host cell plasma membrane
GO:0016021
C:integral to membrane
GO:0030529
C:ribonucleoprotein complex
GO:0019028
C:viral capsid
GO:0019031
C:viral envelope
GO:0055036
C:virion membrane
GO:0005524
F:ATP binding
GO:0008026
F:ATP-dependent helicase activity
GO:0004197
F:cysteine-type endopeptidase activity
GO:0005216
F:ion channel activity
GO:0003723
F:RNA binding
GO:0003968
F:RNA-directed RNA polymerase activity
GO:0004252
F:serine-type endopeptidase activity
GO:0070008
F:serine-type exopeptidase activity
GO:0005198
F:structural molecule activity
GO:0008270
F:zinc ion binding
GO:0006915
P:apoptotic process
GO:0030683
P:evasion by virus of host immune response
GO:0006508
P:proteolysis
GO:0006355
P:regulation of transcription, DNA-dependent
GO:0006351
P:transcription, DNA-dependent
GO:0019087
P:transformation of host cell by virus
GO:0019079
P:viral genome replication
GO:0044167
C:host cell endoplasmic reticulum membrane
GO:0044186
C:host cell lipid particle
GO:0044191
C:host cell mitochondrial membrane
GO:0042025
C:host cell nucleus
GO:0044220
C:host cell perinuclear region of cytoplasm
GO:0020002
C:host cell plasma membrane
GO:0016021
C:integral to membrane
GO:0030529
C:ribonucleoprotein complex
GO:0019028
C:viral capsid
GO:0019031
C:viral envelope
GO:0055036
C:virion membrane
GO:0005524
F:ATP binding
GO:0008026
F:ATP-dependent helicase activity
GO:0004197
F:cysteine-type endopeptidase activity
GO:0005216
F:ion channel activity
GO:0003723
F:RNA binding
GO:0003968
F:RNA-directed RNA polymerase activity
GO:0004252
F:serine-type endopeptidase activity
GO:0070008
F:serine-type exopeptidase activity
GO:0005198
F:structural molecule activity
GO:0008270
F:zinc ion binding
GO:0006915
P:apoptotic process
GO:0030683
P:evasion by virus of host immune response
GO:0006508
P:proteolysis
GO:0006355
P:regulation of transcription, DNA-dependent
GO:0006351
P:transcription, DNA-dependent
GO:0019087
P:transformation of host cell by virus
GO:0019079
P:viral genome replication
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References (8)[1] “The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups.” Tokita H.et.al. 9714232 [2] “Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes.” McLauchlan J.et.al. 10718937 [3] “Structural biology of hepatitis C virus.” Penin F.et.al. 14752815 [4] “An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.” Kim C.S.et.al. 17229681 [5] “The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups.” Tokita H.et.al. 9714232 [6] “Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes.” McLauchlan J.et.al. 10718937 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSTLPKPQKR NQRNTNRRPQ DVKFPGGGQI VGGVYLLPRR GPRLGVRATR KTSERSQPRG 61: RRQPIPKARR QTGRTWAQPG YPWPLYGNEG CGWMGWLLSP RGSRPHWGPN DPRRRSRNLG 121: KVIDTLTCGF ADLMGYIPVV GAPLGGVAAA LAHGVRAVED GINYATGNLP GCSFSIFLLA 181: LLSCLTTPAS AVHYANKSGI YHLTNDCPNS SIVYEAEDFI MHLPGCVPCI KSGNGSSCWL 241: PATLTIAVPN ASIPVRGFRR HVDLMVGAAA FCSAMYVGDL CGGIFLVGQL FSFNPRRHWV 301: VQDCNCSIYV GHITGHRMAW DMMMNWSPTA TLVLSYVMRI PQVIMDIFTG GHWGILAGIL 361: YYSMVANWAK VLCILFLFAG VDATTRTTGA QAARATLGFT GLFQTGAKQN IHLINTNGSW 421: HINRTALNCN DSLNTGFMAA LFYLHKFNST GCPERLSACK SITQFAQGWG PVTYANVSGS 481: SEDRPYCWHY APRPCGVVSA RSVCGPVYCF TPSPVVVGTT DRRGVPTYTW GENESDVFLL 541: ESLRPPAGAW YGCTWMNSTG YTKTCGAPPC HIGPPDQFCP TDCFRKHPEA TYRKCGSGPW 601: LTPRCLVDYP YRLWHYPCTV NYTIHKVRLF INGLEHRFDA ACNWTRGERC ELEDRDRIEM 661: SPLLFSTTEL AILPCSFTTM PALSTGLVHL HQNIVDIQYL YGLAPALVSW AVRWEYVVLA 721: FLLLADARIC ACLWMVLLIS QVEAALENLI VLNAASAASS QGWIYCLVFI CCAWYIKGRV 781: VPGATYAILH LWPLLLLVLA LPQRAYAQDR EQGASIGVVV IAAITIFTLT PAYKTMLVHF 841: LWWNQYFIAR SEALIQQWVP SLRVRGGRDA VILLTCLLHP SLGFDITKML LALLGPLYLL 901: QVSLLRVPYY VRAHALLRVC ILVRRVAGGK YIQAALLKLG AWTGTYIYDH LAPLSTWASD 961: GLRDLAVAVE PVTFSPMEKK IITWGADTAA CGDILAGLPV SARLGHLLFL GPADDMKSMG 1021: WRLLAPITAY CQQTRGLLGT IVTSLTGRDR NVVEGEIQVL STATQSFLGT AINGVMWTVY 1081: HGAGSKTLAG PKGPVCQMYT NVDQDMVGWP APPGTRSLTP CTCGASDLYL VTRNADVIPA 1141: RRRGDTRAGL LSPRPLSTLK GSSGGPLMCP SDHVVGLFRA AVCTRGVAKA LDFVPVENME 1201: TTMRSPVFTD NSTPPAVPQT YQVGYLHAPT GSGKSTKVPA AYASQGYKVL VLNPSVAATL 1261: GFGSYMSTAH GIDPNIRTGV RTITTGGPIT YSTYGKFLAD GGCSGGAYDI IICDECHSTD 1321: PTTVLGIGTV LDQAETAGVR LTVLATATPP GSVTVPHPNI TETALPSTGE VPFYGKAIPL 1381: ECIKGGRHLI FCHSKKKCDE LAKQLRTLGL NAVAFYRGVD VSVIPTAGDV VVCATDALMT 1441: GYTGDFDSVI DCNVAVTQIV DFSLDPTFSI ETTTVPQDAV ARSQRRGRTG RGKPGVYRYV 1501: SQGERPSGMF DTVVLCEAYD VGCAWYELTP SETTVRLRAY LNTPGLPVCQ DHLEFWEGVF 1561: TGMTHIDAHF LSQTKQGGEN FAYLVAYQAT VCARAKAPPP SWDTMWKCLI RLKPMLTGPT 1621: PLLYRLGAVQ NEIITTHPIT KYIMTCMAAD LEVITSTWVL AGGIVAALAA YCLTVGSVVI 1681: CGRIVTSGKP VPLPDREVLY RQFDEMEECS RHIPYLAEGQ QIAEQFKQKI LGLLQNTAKQ 1741: AEDLKPAVQS AWPKLEQFWQ KHLWNFVSGV QYLAGLSTLP GNPAVASLMS FSAALTSPLS 1801: TSTTLLLNIL GGWVASQLAP PTASTAFVVS GLAGAAVGSI GLGKVIIDIL AGYGAGVSGA 1861: LVAFKIMSGE APAVEDMVNL LPALLSPGAL VVGVVCAAVL RRHVGPSEGA TQWMNRLIAF 1921: ASRGNHVSPT HYVPETDASR AVTTILSSLT ITSLLRRLHE WISGDWSAPC SCSWLKDVWD 1981: WVCTVLSDFK TWLRAKLVPT LPGIPFISCQ RGFRGVWRGD GVNYTTCSCG ANITGHVKNG 2041: SMKIVGPKMC SNVWNNRFPI NAITTGPSVP VPEPNYHKAL WRVSAEDYVE VVRVNDHHYI 2101: VGATADNLKC PCQVPAPEFF TEVDGVRLHR FAPPCRPLMR DDITFSVGLS TYVVGSQLPC 2161: EPEPDVVILT SMLTDPDHIT AETAARRLAR GSPPSLASSS ASQLSAPSLK ATCTTAGKHP 2221: DAELIEANLL WRQEVGGNIT RVESENKIIV LDSFDPLIAE TDDREISVGA ECFNPPRPKF 2281: PPALPVWARP DYNPPLLQPW KAPDYEPPLV HGCALPPKGL PPVPPPRKKR VVQLDEGSAK 2341: RALAELAQTS FPPSTATLSE DSGRETSTLS SDMTPPREEA DRASDDGSYS SMPPLEGEPG 2401: DPDLSSGSWS TVSEDHDSVV CCSMSYSWTG ALITPCAAEE EKLPISPLSN ALIRHHNLVY 2461: STTSRSASLR QKKVTFDRVQ VVDQHYYDVL KEIKTKASGV SAKLLSVEEA CALTPPHSAR 2521: SKFGYGAKEV RGLASKAVNH INSVWEDLLE DNSTPIPTTI MAKNEVFCVD AQKGGRKPAR 2581: LIVYPDLGVR VCEKRALYDV TQKLPIAVMG AAYGFQYSPK QRVDYLLKMW RSKKTPMGFS 2641: YDTRCFDSTV TERDIRTEED IYQCCQLDPV AKKAITSLTE RLYCGGPMYN SRGQSCGYRR 2701: CRASGVLTTS LGNTLTCYLK AQAACRAAKL KDFDMLVCGD DLVVISESMG VAEDASALRA 2761: FTEAMTRYSA PPGDDPQPEY DLELITSCSS NVSVAHDGAG QRYYYLTRDP LTPLSRAAWE 2821: TARHTPVNSW LGNIIMYAPT IWVRMVLMTH FFAILQSQEI LHKALDFDMY GVTYSVTPLD 2881: LPYIIQRLHG MAAFSLHGYS PGELNRVASC LRKLGAPPLR AWRHRARAVR AKLIAQGGKH 2941: AICGKYLFNW AVRTKLKLTP LRGAANLDLS GWFVSGGSGG DIFHSVSRAR PRNLLLCLLL 3001: LTVGVGIFLL PAR