| |
|---|---|
| Accession Number: | O39927 |
| Protein Name: | Genome polyprotein |
| Length: | 3018 |
| Molecular Weight: | 329020.00 |
| Species: | Hepatitis C virus genotype 6a (isolate EUHK2) (HCV) [356420] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Host endoplasmic reticulum membrane1 / Single-pass type I membrane protein2 |
| Substrate | cation |
Cross database links:
| Pfam: | PF07652 PF01543 PF01542 PF01539 PF01560 PF01538 PF01006 PF01001 PF01506 PF08300 PF08301 PF12941 PF02907 PF00998 |
|---|---|
Gene Ontology
GO:0044167
C:host cell endoplasmic reticulum membrane
GO:0044186
C:host cell lipid particle
GO:0044191
C:host cell mitochondrial membrane
GO:0042025
C:host cell nucleus
GO:0044220
C:host cell perinuclear region of cytoplasm
GO:0020002
C:host cell plasma membrane
GO:0016021
C:integral to membrane
GO:0030529
C:ribonucleoprotein complex
GO:0019028
C:viral capsid
GO:0019031
C:viral envelope
GO:0055036
C:virion membrane
GO:0005524
F:ATP binding
GO:0008026
F:ATP-dependent helicase activity
GO:0004197
F:cysteine-type endopeptidase activity
GO:0005216
F:ion channel activity
GO:0003723
F:RNA binding
GO:0003968
F:RNA-directed RNA polymerase activity
GO:0004252
F:serine-type endopeptidase activity
GO:0070008
F:serine-type exopeptidase activity
GO:0005198
F:structural molecule activity
GO:0008270
F:zinc ion binding
GO:0006915
P:apoptotic process
GO:0030683
P:evasion by virus of host immune response
GO:0006508
P:proteolysis
GO:0006355
P:regulation of transcription, DNA-dependent
GO:0006351
P:transcription, DNA-dependent
GO:0019087
P:transformation of host cell by virus
GO:0019079
P:viral genome replication
| |
References (4) | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MSTLPKPQRK TKRNTNRRPM DVKFPGGGQI VGGVYLLPRK GPRLGVRATR KTSERSQPRG 61: RRQPIPKARQ PQGRHWAQPG YPWPLYGSEG CGWAGWLLSP RGSRPHWGPN DPRRRSRNLG 121: KVIDTLTCGF ADLMWYIPVV GAPLGGVAAA LAHGVRAIED GINYATGNLP GCSFSIFLLA 181: LLSCLTTPAS ALTYGNSSGL YHLTNDCSNS SIVLEADAMI LHLPGCLPCV RVGNQSTCWH 241: AVSPTLATPN ASTPATGFRR HVDLLAGAAV VCSSLYIGDL CGSLFLAGQL FAFQPRRHWT 301: VQDCNCSIYT GHVTGHKMAW DMMMNWSPTT TLVLSSILRV PEICASVIFG GHWGILLAVA 361: YFGMAGNWLK VLAVLFLFAG VEAQTMIAHG VSQTTSGFAS LLTPGAKQNI QLINTNGSWH 421: INRTALNCND SLQTGFLASL FYTHKFNSSG CPERMAACKP LAEFRQGWGQ ITHKNVSGPS 481: DDRPYCWHYA PRPCEVVPAR SVCGPVYCFT PSPVVVGTTD KRGNPTYTWG ENETDVFMLE 541: SLRPPTGGWF GCTWMNSTGF TKTCGAPPCQ IVPGNYNSSA NELLCPTDCF RKHPEATYQR 601: CGSGPWVTPR CLVDYAYRLW HYPCTVNFTL HKVRMFVGGT EHRFDVACNW TRGERCELHD 661: RNRIEMSPLL FSTTQLSILP CSFSTMPALS TGLIHLHQNI VDVQYLYGVS TNVTSWVVKW 721: EYIVLMFLVL ADARICTCLW LMLLISTVEA AVERLVVLNA ASAAGTAGWW WAVLFLCCVW 781: YVKGRLVPAC TYMALGMWPL LLTILALPPR AYAMDNEQAA SLGAVGLLVI TIFSITPMYK 841: KLLNCFIWWN QYFLARAEAM VHEWVPDLRV RGGRDSIILL TCLLHPQLGF EVTKILLAVL 901: APLYILQYSL LKVPYFVRAH ILLRACLLVR RLAGGKYVQA CLLRLGAWTG TFVYDHLAPL 961: SDWASDGLRD LAVAVEPVIF SPMEKKIITW GADTAACGDI LSGLPVSARL GNLVLLGPAD 1021: DMQRGGWKLL APITAYAQQT RGLVGTIVTS LTGRDKNEVE GEVQVVSTDT QSFVATSING 1081: VMWTVYHGPG FKTLAGPKGP VCQMYTNVDL DLVGWPSPPG ARSLTPCNCG SSDLYLVTRE 1141: ADVIPARRRG DSRAALLSPR PISTLKGSSG GPIMCPSGHV VGLFRAAVCT RGVAKSLDFI 1201: PVENMETTMR SPSFTDNSTP PAVPQTYQVG YLHAPTGSGK STRVPAAYAS QGYKVLVLNP 1261: SVAATLSFGS YMRQAYGVEP NIRTGVRTVT TGGAITYSTY GEFLADGGCS GGAYDIIICD 1321: ECHSTDPTTV LGVGTVLDQA ETAGVRLTVL PTATPPGSVT VPHPNITETA LPTTGEIPFY 1381: GKAIPLEYIK GGRHLIFCHS KKKCDELAGK LKSLGLNAVA FYRGVDVSVI PTSGDVVVCA 1441: TDALMTGYTG DFDSVIDCNV AVTQVVDFSL DPTFSIETTT VPQDAVSRSQ RRGRTGRGKP 1501: GVYRFVSQGE RPSGMFDTVV LCEAYDTGCA WYELTPSETT VRLRAYMNTP GLPVCQDHLE 1561: FWEGVFTGLT HIDAHFLSHT KQAGENFAYL VAYQATVCAR AKAPPPSWDM MWKCLIRLKP 1621: TLTGPTPLLY RLGAVQNGVI TTHPITKYIM TCMSADLEVI TSTWVLVGGV LAALAAYCLS 1681: VGCVVICGRI TLTGKPAVVP DREILYQQFD EMEECSRHIP YLAEGQQIAE QFRQKVLGLL 1741: QASAKQAEEL KPAVHSAWPR VEDFWRKHMW NFVSGIQYLA GLSTLPGNPA VASLMSFTAS 1801: LTSPLRTSQT LLLNILGGWI AAQVAPPPAS TAFVVSGLAG AAVGSIRLGR VLVDVLAGYG 1861: AGVSGALVAF KIMSGECPST EDMVNLLPAL LSPGVALVGV VCAAILRRHV GPAEGANQWM 1921: NRLIAFASRG NHVSPTHYVP ETDASKNVTQ ILTSLTITSL LRRLHQWVNE DTATPCATSW 1981: LRDVWDWVCT VLSDFKVWLQ AKLFPRLPGI PFLSCQAGYR GVWAGDGVCH TTCTCGAVIA 2041: GHVKNGTMKI TGPKTCSNTW HGTFPINATT TGPSTPRPAP NYQRALWRVS AEDYVEVRRL 2101: GDCHYVVGVT AEGLKCPCQV PAPEFFTEVD GVRIHRYAPP CKPLLRDEVT FSVGLSNYAV 2161: GSQLPCEPEP DVTVVTSMLT DPTHITAETA ARRLKKGSPP SLASSSANQL SAPSLRATCT 2221: TSQKHPEMEL LQANLLWKHE MGSHIPRVQS ENKVVVLDSF ELYPLEYEER EISVSVECHR 2281: QPRCKFPPVF PVWARPDNNP PFIQAWQMPG YEPPVVSGCA VAPPKPAPVP PPRRKRLVHL 2341: DESTVSHALA QLADKVFVES SNDPGPSSDS GLSITSPVPP DPTTPEDAGS EAESYSSMPP 2401: LEGEPGDPDL SSGSWSTVSD EDDVVCCSMS YSWTGALITP CAAEEEKLPI NPLSNSLVRH 2461: HNMVYSTTSR SASLRQKKVT FDRVQVFDQH YQDVLKEIKL RASTVQAKLL SIEEACDLTP 2521: SHSARSKYGY GAQDVRSRAS KAVDHIPSVW EGLLEDSDTP IPTTIMAKNE VFCVDPSKGG 2581: RKPARLIVYP DLGVRVCEKM ALYDVTQKLP QAVMGPAYGF QYSPNQRVEY LLKMWRSKKV 2641: PMGFSYDTRC FDSTVTERDI RTENDIYQSC QLDPVARRVV SSLTERLYVG GPMANSKGQS 2701: CGYRRCRASG VLPTSMGNTL TCYLKAQAAC RAANIKDCDM LVCGDDLVVI CESAGVQEDT 2761: ASLRAFTDAM TRYSAPPGDA PQPTYDLELI TSCSSNVSVA HEGNGKKYYY LTRDCTTPLA 2821: RAAWETARHT PVNSWLGNII MFAPTIWVRM VLMNHFFSIL QSQEQLEKAF DFDIYGVTYS 2881: VSPLDLPAII QRLHGMAAFS LHGYSPVELN RVGACLRKLG VLPSRAWRHR ARAVRAKLIA 2941: QGGKAAICGK YLFNWAVKTK LKLTPLVSAS KLDLSGWFVA GYDGGDIYHS VSQARPRFLL 3001: LGLLLLTVGV GIFLLPAR