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1.A.54.3.1 Signal peptide peptidase-2A (SPP2A; 523 aas; 8TMSs) There is no evidence for a transport function for this protease. The functions of these SPP and SPPL proteases have been reviewed (Mentrup et al. 2020).
Accession Number:	Q9JJF9
Protein Name:	Signal peptide peptidase-like 2A
Length:	523
Molecular Weight:	58071.00
Species:	Mus musculus (Mouse) [10090]
Number of TMSs:	9
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate

Entrez Gene ID:	66552
Pfam:	PF02225 PF04258
KEGG:	mmu:66552
Gene Ontology GO:0016021 C:integral to membrane GO:0004190 F:aspartic-type endopeptidase activity
References (1) [1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MGLLHSLHAP AAALLWSCLL GLAAAQEAIL HASTNGVSSL SKDYCMYYNN NWTRLPSSLE 
61:	NATSLSLMNL TGTALCHLSD IPPDGIRNKA VVVHWGPCHF LEKARIAQEG GAAALLIANN 
121:	SVLIPSSRNK STFQNVTVLI AVITQKDFKD MKETLGDDIT VKMYSPSWPN FDYTLVVIFV 
181:	IAVFTVALGG YWSGLIELEN MKSVEDAEDR ETRKKKDDYL TFSPLTVVVF VVICCIMIVL 
241:	LYFFYRWLVY VMIAIFCIAS SMSLYNCLSA LIHRMPCGQC TILCCGKNIK VSLIFLSGLC 
301:	ISVAVVWAVF RNEDRWAWIL QDILGIAFCL NLIKTMKLPN FMSCVILLGL LLIYDVFFVF 
361:	ITPFITKNGE SIMVELAAGP FENAEKLPVV IRVPKLMGYS VMSVCSVPVS VLGFGDIIVP 
421:	GLLIAYCRRF DVQTGSSIYY ISSTIAYAVG MIITFVVLMV MKTGQPALLY LVPCTLITVS 
481:	VVAWSRKEMK KFWKGSSYQV MGHLDYSTNE ENPVTTDEQI VQQ

1.A.54.3.1
Signal peptide peptidase-2A (SPP2A; 523 aas; 8TMSs) There is no evidence for a transport function for this protease. The functions of these SPP and SPPL proteases have been reviewed (Mentrup et al. 2020).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.A.54.3.1Signal peptide peptidase-2A (SPP2A; 523 aas; 8TMSs) There is no evidence for a transport function for this protease. The functions of these SPP and SPPL proteases have been reviewed (Mentrup et al. 2020).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.A.54.3.1
Signal peptide peptidase-2A (SPP2A; 523 aas; 8TMSs) There is no evidence for a transport function for this protease. The functions of these SPP and SPPL proteases have been reviewed (Mentrup et al. 2020).