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1.A.57.1.5
Orf3a of 275 aas and 3 central TMSs. Orf3a forms homodimers and homotetramers. Both carry a PDZ-binding domain, lending them the versatility to interact with more than 400 target proteins in infected host cells. Structural considerations have been discussed (Barrantes 2021). Naturally occurring mutations in ORF3a are common and have been analyzed, and 28 fully concerved residues in 70,000 sequences that probably have structural or functional roles weree also identified (Bianchi et al. 2020). Viroporin 3a exhibits allosteric properties (Tee et al. 2021).

Accession Number:P0DTC3
Protein Name:ORF3a protein
Length:275
Molecular Weight:31123.00
Species:Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) [2697049]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Virion1
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDLFMRIFTI GTVTLKQGEI KDATPSDFVR ATATIPIQAS LPFGWLIVGV ALLAVFQSAS 
61:	KIITLKKRWQ LALSKGVHFV CNLLLLFVTV YSHLLLVAAG LEAPFLYLYA LVYFLQSINF 
121:	VRIIMRLWLC WKCRSKNPLL YDANYFLCWH TNCYDYCIPY NSVTSSIVIT SGDGTTSPIS 
181:	EHDYQIGGYT EKWESGVKDC VVLHSYFTSD YYQLYSTQLS TDTGVEHVTF FIYNKIVDEP 
241:	EEHVQIHTID GSSGVVNPVM EPIYDEPTTT TSVPL