| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.A.57.1.1 | SARS-CoV Viroporin tetrameric ion channel. Protein 3a is of 274 aas and 3 TMSs. It activates the Nod-like receptor family members which are pyrin domain-containing 3 (NLRP3)proteins that regulate the secretion of proinflammatory cytokines such as interleukin 1 beta (IL-1beta) and IL-18. K+ efflux and mitochondrial reactive oxygen species are important for SARS-CoV 3a-induced NLRP3 inflammasome activation (Chen et al. 2019). Viroporin 3a exhibits allosteric properties (Tee et al. 2021). | Viruses |
Nidovirales | SARS-Caronavirus Viroporin (Protein 3a) (P59632) |
|
1.A.57.1.2 | Orf3 of 249 aas and 3 putative TMSs | Viruses |
Nidovirales | Orf3 of Zaria bat coronavirus (F1BYM0) |
|
1.A.57.1.3 | Viruses |
Nidovirales | NS3 of Bat coronavirus HKU9-5-1 (E0ZN37) | |
|
1.A.57.1.4 | Orf3 of 238aas and 3 putative TMSs | Viruses |
Nidovirales | Orf3 of Eidolon bat coronavirus (F1DAZ2) |
|
1.A.57.1.5 | Orf3a of 275 aas and 3 central TMSs. Orf3a forms homodimers and homotetramers. Both carry a PDZ-binding domain, lending them the versatility to interact with more than 400 target proteins in infected host cells. Structural considerations have been discussed (Barrantes 2021). Naturally occurring mutations in ORF3a are common and have been analyzed, and 28 fully concerved residues in 70,000 sequences that probably have structural or functional roles weree also identified (Bianchi et al. 2020). Viroporin 3a exhibits allosteric properties (Tee et al. 2021). | Viruses |
Nidovirales | Orf3a of severe acute respiratory syndrome (SARS) coronavirus 2 |