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| Accession Number: | Q09274 |
| Protein Name: | Degenerin-like protein unc-105 |
| Length: | 887 |
| Molecular Weight: | 100333.00 |
| Species: | Caenorhabditis elegans [6239] |
| Number of TMSs: | 2 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | sodium(1+) |
Cross database links:
| RefSeq: | NP_001122595.1 NP_495702.1 |
|---|---|
| Entrez Gene ID: | 174306 |
| Pfam: | PF00858 |
| KEGG: | cel:C41C4.5 |
Gene Ontology
GO:0005272
F:sodium channel activity
GO:0006816
P:calcium ion transport
GO:0030154
P:cell differentiation
GO:0015693
P:magnesium ion transport
GO:0007517
P:muscle organ development
GO:0006814
P:sodium ion transport
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References (8)[1] “Interaction between a putative mechanosensory membrane channel and a collagen.” Liu J.et.al. 8662524 [2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.” The C. elegans sequencing consortiumet.al. 9851916 [3] “Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans.” Park E.-C.et.al. 3744028 [4] “C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle.” Park E.-C.et.al. 3744029 [5] “The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.” Garcia-Anoveros J.et.al. 9655510 [6] “Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle.” Jospin M.et.al. 15020702 [7] “An amiloride-sensitive H+-gated Na+ channel in Caenorhabditis elegans body wall muscle cells.” Jospin M.et.al. 15254157 [8] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.” Kaji H.et.al. 17761667
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAEDRIKSKL RRPASIESTM SSRTKPRHKP SPMSILMPHL MVGESFRKYR PHGLRNIRMN 61: GHLDWNQLRK SFEKQSTFHG ISHAATADGK WRWFWYTAFT ICLLALLIQI FFLISKYRQY 121: GKTVDLDLKF ENAPFPSITI CNLNPYKKSA IQSNPNTKAM MEAYSRRIGS GDKTEGIAAA 181: LSATGGLHAK VRRAKRKAKG KPRLRDRRYH QAFAQCLCDI EQLTGDRKGS CFAAFKGKIE 241: IDTNNTAGFM NLHTSRCLCQ LDTVSKALWP CFPYSSWKEK LCSECVDNTG HCPMRFYKGN 301: ELYENIKEQV DLCLCHKEYN HCVSTRDDGI ILEISPNDEL NDLDIGKKIA SQLSAQQEKQ 361: AEVTTTEAPT VTQALGFEEL TDDIAITSQA QENLMFAVGE MSEKAKESMS YELDELVLKC 421: SFNQKDCQMD RDFTLHYDNT FGNCYTFNYN RTAEVASHRA GANYGLRVLL YANVSEYLPT 481: TEAVGFRITV HDKHIVPFPD AFGYSAPTGF MSSFGVRMKQ FIRLEPPYGH CRHGGEDAAT 541: FVYTGFQYSV EACHRSCAQK VIVEACGCAD PMYPVAEMFG NNTKPCQAVN MDQRECLRNT 601: TLWLGELYSK GKEAIIPDCY CHQPCQETNY EVTYSSARWP SGSAKVMECL PGDFLCLEKY 661: RKNAAMVQIF YEELNYETMQ ESPAYTLTSV LADLGGLTGL WIGASVVSLL EIVTLIVFAT 721: QAYVRKRKGS ISAQSHHSVP VHRASRVSLN TLHKSSTTQS VKLSVMDIRS IKSIHSNHSS 781: KSKQSILIED LPPAIQEQSD DEEETTESSR TNGSCRYLAP GEDLPCLCKY HPDGSIRIMK 841: ALCPVHGYMV RRNYDYSVSN SEEEDAEDEV HREPEPFYSA PYEHRKK