1.A.69.5.2
Odorant Receptor 4, OR4 or GPROR4, of 406 aas and 7 or 8 TMSs; if 8, the C-terminal TMS may not be a TMS. This odorant receptor specifically recognizes the human odorant
sulcatone (6-methylhept-5-en-2-onesul), a volatile odorant emitted at
uniquely high levels in humans, thereby playing a key role in mosquito's
preference in biting human compared to other animals (McBride et al. 2014). Aedes aegypti is a vector for viruses that spread diseases like dengue, Zika and Chikungunya. Tiwari and Sowdhamini 2023 have modeled the full-length structure of OR4 and the ORco of A. aegypti.
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| Accession Number: | Q16EI9 |
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| Protein Name: | Odorant receptor 4 |
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| Length: | 406 |
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| Molecular Weight: | 46099.00 |
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| Species: | Aedes aegypti (Yellowfever mosquito) [7159] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion |
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1: MTQSLEFDQT FGFIAKVLQM IGYPSCLAPY PTTFASRLKS SAGFVVCFLM LTYCVFGQII
61: NIGLLMMGHR QTDQVVEEVA IQVSSTGFCI IGLAKMYSLS YNRAILSWLI ADFRVKWNAG
121: ELTDKDRSIR DGTLRPTVAI TTVAALGNII MVSAFNFQPV VEMIYGRVVT GEWVKLFPYV
181: IWFPFNSTHG AIYYLVYLFE VYSGVIVAVG NVGFNCIFCL LTSHLSMQLK LLCSWIEDMV
241: EVEDEKGVQS KKKLYRIVRY HQDLIRGRNA LQSMFSTTLF LNFSASSVLM CMQLYLITTA
301: GITLMVKFTL FMLCILMEIF ILCYYGEEIL ANSSSIAAGA FNSNWYQSKV SQQNPRFGKN
361: LIPIIQQGQR PMVLTAWKFW PITIRTFSAI LQTSWSYFTL LKTVMH