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1.A.69.5.2
Odorant Receptor 4, OR4 or GPROR4, of 406 aas and 7 or 8 TMSs; if 8, the C-terminal TMS may not be a TMS. This odorant receptor specifically recognizes the human odorant sulcatone (6-methylhept-5-en-2-onesul), a volatile odorant emitted at uniquely high levels in humans, thereby playing a key role in mosquito's preference in biting human compared to other animals (McBride et al. 2014). Aedes aegypti is a vector for viruses that spread diseases like dengue, Zika and Chikungunya. Tiwari and Sowdhamini 2023 have modeled the full-length structure of OR4 and the ORco of A. aegypti.

Accession Number:Q16EI9
Protein Name:Odorant receptor 4
Length:406
Molecular Weight:46099.00
Species:Aedes aegypti (Yellowfever mosquito) [7159]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ion

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FASTA formatted sequence
1:	MTQSLEFDQT FGFIAKVLQM IGYPSCLAPY PTTFASRLKS SAGFVVCFLM LTYCVFGQII 
61:	NIGLLMMGHR QTDQVVEEVA IQVSSTGFCI IGLAKMYSLS YNRAILSWLI ADFRVKWNAG 
121:	ELTDKDRSIR DGTLRPTVAI TTVAALGNII MVSAFNFQPV VEMIYGRVVT GEWVKLFPYV 
181:	IWFPFNSTHG AIYYLVYLFE VYSGVIVAVG NVGFNCIFCL LTSHLSMQLK LLCSWIEDMV 
241:	EVEDEKGVQS KKKLYRIVRY HQDLIRGRNA LQSMFSTTLF LNFSASSVLM CMQLYLITTA 
301:	GITLMVKFTL FMLCILMEIF ILCYYGEEIL ANSSSIAAGA FNSNWYQSKV SQQNPRFGKN 
361:	LIPIIQQGQR PMVLTAWKFW PITIRTFSAI LQTSWSYFTL LKTVMH