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1.A.7.1.1
ATP-gated cation channel (purinoceptor or ATP-neuroreceptor). Residues Glu52-Gly96 play roles in agonist binding and channel gating (Allsopp et al., 2011).  The rat protein is 89% identical to the human ortholog. Mutations likely to confer ivermectin sensitivity to human P2X1 have been proposed (Pasqualetto et al. 2018).

Accession Number:P47824
Protein Name:P2X1 aka P2RX1
Length:399
Molecular Weight:44957.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

RefSeq: NP_037129.1   
Entrez Gene ID: 25505   
Pfam: PF00864   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0045121 C:membrane raft
GO:0005886 C:plasma membrane
GO:0043234 C:protein complex
GO:0019717 C:synaptosome
GO:0005524 F:ATP binding
GO:0008144 F:drug binding
GO:0004931 F:extracellular ATP-gated cation channel acti...
GO:0005515 F:protein binding
GO:0008270 F:zinc ion binding
GO:0006811 P:ion transport
GO:0051291 P:protein heterooligomerization
GO:0051260 P:protein homooligomerization
GO:0019228 P:regulation of action potential in neuron
GO:0008217 P:regulation of blood pressure
GO:0035249 P:synaptic transmission, glutamatergic
GO:0042310 P:vasoconstriction

References (3)

[1] “A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP.”  Valera S.et.al.   7523951
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Identification of mRNAs associated with programmed cell death in immature thymocytes.”  Owens G.P.et.al.   2072913

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MARRLQDELS AFFFEYDTPR MVLVRNKKVG VIFRLIQLVV LVYVIGWVFV YEKGYQTSSD 
61:	LISSVSVKLK GLAVTQLQGL GPQVWDVADY VFPAHGDSSF VVMTNFIVTP QQTQGHCAEN 
121:	PEGGICQDDS GCTPGKAERK AQGIRTGNCV PFNGTVKTCE IFGWCPVEVD DKIPSPALLR 
181:	EAENFTLFIK NSISFPRFKV NRRNLVEEVN GTYMKKCLYH KIQHPLCPVF NLGYVVRESG 
241:	QDFRSLAEKG GVVGITIDWK CDLDWHVRHC KPIYQFHGLY GEKNLSPGFN FRFARHFVQN 
301:	GTNRRHLFKV FGIHFDILVD GKAGKFDIIP TMTTIGSGIG IFGVATVLCD LLLLHILPKR 
361:	HYYKQKKFKY AEDMGPGEGE HDPVATSSTL GLQENMRTS