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1.A.7.1.4
The P2X4 receptor (P2X4R) of the zebrafish of 389 aas and 2 TMSs. The 3-d structure is known in its closed, resting state (Kawate et al., 2009).  A hift of L340 packing between different sites may alter the side-chain orientation that frees or occludes the pore. L340, A344 and A347 may also gate the pore by a expansion-contraction mechanism (Li 2015). Ivermectin binds to the transmembrane domain while Zn2+ binds to the extracellular domain, but they exhbit additive cooperativity (Latapiat et al. 2017).

Accession Number:Q98TZ0
Protein Name:P2X purinoceptor
Length:389
Molecular Weight:43957.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

RefSeq: NP_705939.1   
Entrez Gene ID: 259258   
Pfam: PF00864   
KEGG: dre:259258   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0005216 F:ion channel activity
GO:0004872 F:receptor activity
GO:0006811 P:ion transport

References (1)

[1] “Cloning and characterization of two novel zebrafish P2X receptor subunits.”  Diaz-Hernandez M.et.al.   12127972

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSESVGCCDS VSQCFFDYYT SKILIIRSKK VGTLNRFTQA LVIAYVIGYV CVYNKGYQDT 
61:	DTVLSSVSTK VKGIALTNTS ELGERIWDVA DYIIPPQEDG SFFVLTNMII TTNQTQSKCA 
121:	ENPTPASTCT SHRDCKRGFN DARGDGVRTG RCVSYSASVK TCEVLSWCPL EKIVDPPNPP 
181:	LLADAENFTV LIKNNIRYPK FNFNKRNILP NINSSYLTHC VFSRKTDPDC PIFRLGDIVG 
241:	EAEEDFQIMA VHGGVMGVQI RWDCDLDMPQ SWCVPRYTFR RLDNKDPDNN VAPGYNFRFA 
301:	KYYKNSDGTE TRTLIKGYGI RFDVMVFGQA GKFNIIPTLL NIGAGLALLG LVNVICDWIV 
361:	LTFMKRKQHY KEQKYTYVDD FGLLHNEDK