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Accession Number: | Q99571 |
Protein Name: | P2X purinoceptor 4 |
Length: | 388 |
Molecular Weight: | 43369.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 2 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | ion |
Cross database links:
Entrez Gene ID: | 5025 |
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Pfam: | PF00864 |
KEGG: | hsa:5025 hsa:5025 |
Gene Ontology
GO:0030054
C:cell junction
GO:0005887
C:integral to plasma membrane
GO:0048471
C:perinuclear region of cytoplasm
GO:0005524
F:ATP binding
GO:0045296
F:cadherin binding
GO:0005507
F:copper ion binding
GO:0004931
F:extracellular ATP-gated cation channel activity
GO:0042803
F:protein homodimerization activity
GO:0001614
F:purinergic nucleotide receptor activity
GO:0005102
F:receptor binding
GO:0008270
F:zinc ion binding
GO:0042118
P:endothelial cell activation
GO:0051899
P:membrane depolarization
GO:0010614
P:negative regulation of cardiac muscle hypertrophy
GO:0010524
P:positive regulation of calcium ion transport into cytosol
GO:0050850
P:positive regulation of calcium-mediated signaling
GO:0045429
P:positive regulation of nitric oxide biosynthetic process
GO:0032308
P:positive regulation of prostaglandin secretion
GO:0042981
P:regulation of apoptotic process
GO:0008217
P:regulation of blood pressure
GO:0055117
P:regulation of cardiac muscle contraction
GO:0002028
P:regulation of sodium ion transport
GO:0055119
P:relaxation of cardiac muscle
GO:0033198
P:response to ATP
GO:0034405
P:response to fluid shear stress
GO:0019233
P:sensory perception of pain
GO:0001894
P:tissue homeostasis
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References (6)[1] “Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.” Garcia-Guzman M.et.al. 9016352 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MAGCCAALAA FLFEYDTPRI VLIRSRKVGL MNRAVQLLIL AYVIGWVFVW EKGYQETDSV 61: VSSVTTKVKG VAVTNTSKLG FRIWDVADYV IPAQEENSLF VMTNVILTMN QTQGLCPEIP 121: DATTVCKSDA SCTAGSAGTH SNGVSTGRCV AFNGSVKTCE VAAWCPVEDD THVPQPAFLK 181: AAENFTLLVK NNIWYPKFNF SKRNILPNIT TTYLKSCIYD AKTDPFCPIF RLGKIVENAG 241: HSFQDMAVEG GIMGIQVNWD CNLDRAASLC LPRYSFRRLD TRDVEHNVSP GYNFRFAKYY 301: RDLAGNEQRT LIKAYGIRFD IIVFGKAGKF DIIPTMINIG SGLALLGMAT VLCDIIVLYC 361: MKKRLYYREK KYKYVEDYEQ GLASELDQ